Evolving view of the in-vivo kinetics of chronic lymphocytic leukemia B cells.

Nicholas Chiorazzi, Manlio Ferrarini

Research output: Contribution to journalArticle

Abstract

B-cell chronic lymphocytic leukemia (B-CLL) has long been considered a disease of "accumulation," due to a presumed defect in programmed cell death. Recent data, however, suggest that B-CLL cells are born at a normal to an accelerated rate, with the rate of proliferation varying among patients. In addition, differences in birth rates, activation state, and inducibility appear to exist among subpopulations of cells within individual leukemic clones. The extent to which such dissimilarities influence clinical course and outcome is still unclear. This review examines the evidence supporting the existence of a proliferative compartment in B-CLL and the role that proliferating cells might play in the progression and evolution of this disease.

Fingerprint

B-Cell Chronic Lymphocytic Leukemia
Birth Rate
Disease Progression
Cell Death
Clone Cells

ASJC Scopus subject areas

  • Medicine(all)

Cite this

@article{4439d03063114b1b8bf976d22ce65aa9,
title = "Evolving view of the in-vivo kinetics of chronic lymphocytic leukemia B cells.",
abstract = "B-cell chronic lymphocytic leukemia (B-CLL) has long been considered a disease of {"}accumulation,{"} due to a presumed defect in programmed cell death. Recent data, however, suggest that B-CLL cells are born at a normal to an accelerated rate, with the rate of proliferation varying among patients. In addition, differences in birth rates, activation state, and inducibility appear to exist among subpopulations of cells within individual leukemic clones. The extent to which such dissimilarities influence clinical course and outcome is still unclear. This review examines the evidence supporting the existence of a proliferative compartment in B-CLL and the role that proliferating cells might play in the progression and evolution of this disease.",
author = "Nicholas Chiorazzi and Manlio Ferrarini",
year = "2006",
language = "English",
journal = "Hematology / the Education Program of the American Society of Hematology. American Society of Hematology. Education Program",
issn = "1520-4391",
publisher = "American Society of Hematology",

}

TY - JOUR

T1 - Evolving view of the in-vivo kinetics of chronic lymphocytic leukemia B cells.

AU - Chiorazzi, Nicholas

AU - Ferrarini, Manlio

PY - 2006

Y1 - 2006

N2 - B-cell chronic lymphocytic leukemia (B-CLL) has long been considered a disease of "accumulation," due to a presumed defect in programmed cell death. Recent data, however, suggest that B-CLL cells are born at a normal to an accelerated rate, with the rate of proliferation varying among patients. In addition, differences in birth rates, activation state, and inducibility appear to exist among subpopulations of cells within individual leukemic clones. The extent to which such dissimilarities influence clinical course and outcome is still unclear. This review examines the evidence supporting the existence of a proliferative compartment in B-CLL and the role that proliferating cells might play in the progression and evolution of this disease.

AB - B-cell chronic lymphocytic leukemia (B-CLL) has long been considered a disease of "accumulation," due to a presumed defect in programmed cell death. Recent data, however, suggest that B-CLL cells are born at a normal to an accelerated rate, with the rate of proliferation varying among patients. In addition, differences in birth rates, activation state, and inducibility appear to exist among subpopulations of cells within individual leukemic clones. The extent to which such dissimilarities influence clinical course and outcome is still unclear. This review examines the evidence supporting the existence of a proliferative compartment in B-CLL and the role that proliferating cells might play in the progression and evolution of this disease.

UR - http://www.scopus.com/inward/record.url?scp=39049186475&partnerID=8YFLogxK

UR - http://www.scopus.com/inward/citedby.url?scp=39049186475&partnerID=8YFLogxK

M3 - Article

C2 - 17124072

AN - SCOPUS:39049186475

JO - Hematology / the Education Program of the American Society of Hematology. American Society of Hematology. Education Program

JF - Hematology / the Education Program of the American Society of Hematology. American Society of Hematology. Education Program

SN - 1520-4391

ER -