Abstract
B-cell chronic lymphocytic leukemia (B-CLL) has long been considered a disease of "accumulation," due to a presumed defect in programmed cell death. Recent data, however, suggest that B-CLL cells are born at a normal to an accelerated rate, with the rate of proliferation varying among patients. In addition, differences in birth rates, activation state, and inducibility appear to exist among subpopulations of cells within individual leukemic clones. The extent to which such dissimilarities influence clinical course and outcome is still unclear. This review examines the evidence supporting the existence of a proliferative compartment in B-CLL and the role that proliferating cells might play in the progression and evolution of this disease.
| Original language | English |
|---|---|
| Journal | Hematology / the Education Program of the American Society of Hematology. American Society of Hematology. Education Program |
| Publication status | Published - 2006 |
Fingerprint
ASJC Scopus subject areas
- Medicine(all)
Cite this
Evolving view of the in-vivo kinetics of chronic lymphocytic leukemia B cells. / Chiorazzi, Nicholas; Ferrarini, Manlio.
In: Hematology / the Education Program of the American Society of Hematology. American Society of Hematology. Education Program, 2006.Research output: Contribution to journal › Article
}
TY - JOUR
T1 - Evolving view of the in-vivo kinetics of chronic lymphocytic leukemia B cells.
AU - Chiorazzi, Nicholas
AU - Ferrarini, Manlio
PY - 2006
Y1 - 2006
N2 - B-cell chronic lymphocytic leukemia (B-CLL) has long been considered a disease of "accumulation," due to a presumed defect in programmed cell death. Recent data, however, suggest that B-CLL cells are born at a normal to an accelerated rate, with the rate of proliferation varying among patients. In addition, differences in birth rates, activation state, and inducibility appear to exist among subpopulations of cells within individual leukemic clones. The extent to which such dissimilarities influence clinical course and outcome is still unclear. This review examines the evidence supporting the existence of a proliferative compartment in B-CLL and the role that proliferating cells might play in the progression and evolution of this disease.
AB - B-cell chronic lymphocytic leukemia (B-CLL) has long been considered a disease of "accumulation," due to a presumed defect in programmed cell death. Recent data, however, suggest that B-CLL cells are born at a normal to an accelerated rate, with the rate of proliferation varying among patients. In addition, differences in birth rates, activation state, and inducibility appear to exist among subpopulations of cells within individual leukemic clones. The extent to which such dissimilarities influence clinical course and outcome is still unclear. This review examines the evidence supporting the existence of a proliferative compartment in B-CLL and the role that proliferating cells might play in the progression and evolution of this disease.
UR - http://www.scopus.com/inward/record.url?scp=39049186475&partnerID=8YFLogxK
UR - http://www.scopus.com/inward/citedby.url?scp=39049186475&partnerID=8YFLogxK
M3 - Article
C2 - 17124072
AN - SCOPUS:39049186475
JO - Hematology / the Education Program of the American Society of Hematology. American Society of Hematology. Education Program
JF - Hematology / the Education Program of the American Society of Hematology. American Society of Hematology. Education Program
SN - 1520-4391
ER -