Ex-FABP, extracellular fatty acid binding protein, is a stress lipocalin expressed during chicken embryo development

Fiorella Descalzi Cancedda, Beatrice Dozin, Barbara Zerega, Silvia Cermelli, Chiara Gentili, Ranieri Cancedda

Research output: Contribution to journalArticle

Abstract

Extracellular Fatty Acid Binding Protein (Ex-FABP) is a 21 kDa lipocalin, expressed during chicken embryo development in hypertrophic cartilage, in muscle fibres and in blood granulocyte. The protein selectively binds with high affinity fatty acids, preferably long chain unsaturated fatty acids in chondrocyte and myoblast cultures Ex-FABP expression is increased by inflammatory-agents and repressed by anti-inflammatory-agents. In adult cartilage, Ex-FABP is expressed only in pathological conditions such as in dyschondroplastic and osteoarthritic chicken cartilage. We propose that lipocalin Ex-FABP represents a stress protein physiologically expressed in tissues where active remodelling is taking place during development and also present in tissues characterized by a stress response due to pathological conditions.

Original languageEnglish
Pages (from-to)221-225
Number of pages5
JournalMolecular and Cellular Biochemistry
Volume239
Issue number1-2
DOIs
Publication statusPublished - Oct 2002

Keywords

  • Extracellular fatty acid binding protein
  • Hypertrophic cartilage
  • Lipocalin
  • Stress protein

ASJC Scopus subject areas

  • Cell Biology
  • Clinical Biochemistry
  • Genetics
  • Molecular Biology

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