Ex vivo effect of pidotimod on peripheral blood mononuclear cell immune functions: Study of an elderly population

M. O. Borghi, C. Fain, W. Barcellini, N. Del Papa, L. La Rosa, F. Nicoletti, C. Uslenghi, P. L. Meroni

Research output: Contribution to journalArticle

Abstract

The effect of the new immunomodulating synthetic dipeptide pidotimod on some human immune functions was studied after ex vivo administration in healthy elderly subjects, as a model of acquired immune deficit. Results showed that treatment with pidotimod enhanced mitogen-induced lymphocyte proliferation and γ-IFN production. The drug slightly reduced IL-6 content in supernatants from adherent monocytes, while it did not significantly affect polyclonal Ig synthesis. These findings further support the biological response modifying activity of pidotimod in human subjects.

Original languageEnglish
Pages (from-to)35-39
Number of pages5
JournalInternational Journal of Immunotherapy
Volume10
Issue number1
Publication statusPublished - 1994

ASJC Scopus subject areas

  • Immunology and Allergy
  • Immunology

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