Ex Vivo Fluorescence Microscopy: Clinical Applications in Dermatology and Surgical Pathology

C. Longo, S. Gardini, S. Piana, F. Castagnetti, G. Argenziano, G. Pellacani, M. Ragazzi

Research output: Chapter in Book/Report/Conference proceedingChapter

Abstract

Ex vivo fluorescence confocal microscopy (FCM) is a novel imaging technique that can be applied on freshly excised tumors for rapid bedside pathology for Mohs surgery and in general pathology. The first clinical application of FCM was on skin cancers such as basal cell carcinoma, for which it has demonstrated high sensitivity and specificity for margin assessment. Later, FCM was applied on freshly excised specimens in general pathology and in particular on breast cancer samples. Preliminary studies highlighted the potential applicability of this fascinating new tool to characterize the tumor and obtain a rapid detection of residual tumor in surgical margins.

Original languageEnglish
Title of host publicationImaging in Dermatology
PublisherElsevier Inc.
Pages95-102
Number of pages8
ISBN (Print)9780128028384
DOIs
Publication statusPublished - Aug 19 2016

Keywords

  • Breast cancer
  • Ex vivo fluorescence confocal microscopy
  • Histopathology
  • Mohs surgery
  • Skin cancer

ASJC Scopus subject areas

  • Medicine(all)

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