Exacerbation of experimental autoimmune encephalomyelitis by passive transfer of IgG antibodies from a multiple sclerosis patient responsive to immunoadsorption

Rosetta Pedotti, Silvia Musio, Stefano Scabeni, Cinthia Farina, Pietro Luigi Poliani, Emanuela Colombo, Massimo Costanza, Angela Berzi, Fabrizio Castellucci, Emilio Ciusani, Paolo Confalonieri, Bernhard Hemmer, Renato Mantegazza, Carlo Antozzi

Research output: Contribution to journalArticlepeer-review

Abstract

The pathogenic role of antibodies in multiple sclerosis (MS) is still controversial. We transferred to mice with experimental autoimmune encephalomyelitis (EAE), animal model of MS, IgG antibodies purified from a MS patient presenting a dramatic clinical improvement during relapse after selective IgG removal with immunoadsorption. Passive transfer of patient's IgG exacerbated motor paralysis and increased mouse central nervous system (CNS) inflammation and demyelination. Binding of patient's IgG was demonstrated in mouse CNS, with a diffuse staining of white matter oligodendrocytes. These data support a growing body of evidence that antibodies can play an important role in the pathobiology of MS.

Original languageEnglish
Pages (from-to)19-26
Number of pages8
JournalJournal of Neuroimmunology
Volume262
Issue number1-2
DOIs
Publication statusPublished - 2013

Keywords

  • Antibodies
  • Demyelination
  • Experimental autoimmune encephalomyelitis
  • Immunoadsorption
  • Multiple sclerosis
  • Plasma exchange

ASJC Scopus subject areas

  • Immunology
  • Clinical Neurology
  • Immunology and Allergy
  • Neurology

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