Exaggerated local hand sympathetic but not renin-angiotensin system activation in patients with primary Raynaud's phenomenon

Mirella Coppo, Maria Boddi, Loredana Poggesi, Manuela Bandinelli, Rosanna Abbate, Gian Franco Gensini

Research output: Contribution to journalArticle

Abstract

In Raynaud's disease (RD), an overactivity of sympathetic nervous system (SNS) was hypothesized but only indirect proofs were obtained. Complex interactions between the renin-angiotensin system (RAS) and SNS were reported without clear demonstrations of a RAS involvement. Recently, the use of ACE inhibitors and AT1 receptor antagonists in RD patients showed mixed results. The study of total and regional kinetics of tritiated noradrenaline (NA) and the measurements of local Angiotensin (Ang) I and II arterial-venous gradient were performed in 10 RD patients and 10 controls both in rest conditions and following a cold pressor test (CPT). Hand blood flow (HBF) was measured by strain-gauge plethysmography. Baseline HBF was slightly lower in patients than in controls, but during CPT, it significantly decreased only in RD patients (P 3H)-NA clearance and spillover were similar in the two groups throughout the study. On the contrary, baseline hand NA spillover was higher in RD patients than in controls and the difference further increased during CPT. Hand NA spillover was linearly related to HBF (P 

Original languageEnglish
Pages (from-to)128-134
Number of pages7
JournalMicrovascular Research
Volume71
Issue number2
DOIs
Publication statusPublished - Mar 2006

Keywords

  • Raynaud's phenomenon
  • Renin angiotensin system
  • Sympathetic nervous system

ASJC Scopus subject areas

  • Biochemistry
  • Cardiology and Cardiovascular Medicine

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