Excess of nonceruloplasmin serum copper in AD correlates with MMSE, CSF β-amyloid, and h-tau

R. Squitti, G. Barbati, L. Rossi, M. Ventriglia, G. Dal Forno, S. Cesaretti, F. Moffa, I. Caridi, E. Cassetta, P. Pasqualetti, L. Calabrese, D. Lupoi, P. M. Rossini

Research output: Contribution to journalArticlepeer-review

Abstract

OBJECTIVE: To assess whether serum copper in Alzheimer disease (AD) correlates with cognitive scores, β-amyloid, and other CSF markers of neurodegeneration. METHODS: The authors studied copper, ceruloplasmin, total peroxide, and antioxidants levels (TRAP) in serum; β-amyloid in plasma; and copper, β-amyloid, h-tau, and P-tau in the CSF of 28 patients with AD and 25 healthy controls, in relation to clinical status. RESULTS: Serum copper (p <0.0001), peroxides (p = 0.002), a copper fraction unexplained by ceruloplasmin (p <0.0001), and CSF h-tau (p = 0.001) were increased in AD, whereas serum TRAP (p = 0.03) and CSF β-amyloid were decreased (p <0.0001). Plasma β-amyloid increased with age in healthy controls (r = 0.6; p = 0.05). CSF markers of AD correlated with serum copper variables. CSF copper was partially dependent on the serum copper fraction unexplained by ceruloplasmin (t = 2.2, p = 0.04). CSF β-amyloid seemed to be related to serum copper (r = -0.46; p = 0.002). Mini-Mental Status Examination scores correlated positively with β-amyloid (r = 0.46, p = 0.002) and inversely with copper unexplained by ceruloplasmin (r = -0.45, p = 0.003). CONCLUSIONS: The authors' results confirm the existence of changes in copper component distribution, particularly the copper fraction unexplained by ceruloplasmin and support the hypothesis of a β-amyloid and copper connection in Alzheimer disease.

Original languageEnglish
Pages (from-to)76-82
Number of pages7
JournalNeurology
Volume67
Issue number1
DOIs
Publication statusPublished - Jul 2006

ASJC Scopus subject areas

  • Neuroscience(all)

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