Excessive daytime sleepiness and levodopa in Parkinson's disease: Polygraphic, placebo-controlled monitoring

Manuela Contin, Federica Provini, Paolo Martinelli, Roberto Riva, Fiorenzo Albani, Roberto Vetrugno, Caterina Lombardi, Pasquale Montagna, Agostino Baruzzi

Research output: Contribution to journalArticle

Abstract

The authors performed 72-hour polysomnography, including a levodopaplacebo-controlled choice reaction time test with continuous monitoring of cardiovascular variables in two patients with Parkinson's disease complaining of excessive day-time sleepiness on levodopa monotherapy. The subacute levodopa challenge was accompanied by physiologic sleep episodes, worsened reaction times, and a reduction in mean blood pressure and heart rate over baseline values, linked temporally to the sleep episodes.

Original languageEnglish
Pages (from-to)115-118
Number of pages4
JournalClinical Neuropharmacology
Volume26
Issue number3
DOIs
Publication statusPublished - May 2003

Keywords

  • Cardiovascular variables
  • Choice reaction times
  • Excessive daytime sleepiness
  • Levodopa
  • Parkinson's disease

ASJC Scopus subject areas

  • Pharmacology (medical)
  • Clinical Neurology
  • Neuroscience(all)
  • Pharmacology, Toxicology and Pharmaceutics(all)

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