TY - JOUR
T1 - Excessive daytime Sleepiness in Multiple System Atrophy (SLEEMSA study)
AU - Moreno-López, Claudia
AU - Santamaría, Joan
AU - Salamero, Manuel
AU - Del Sorbo, Francesca
AU - Albanese, Alberto
AU - Pellecchia, Maria Teresa
AU - Barone, Paolo
AU - Overeem, Sebastiaan
AU - Bloem, Bastiaan
AU - Aarden, Willemijn
AU - Canesi, Margherita
AU - Antonini, Angelo
AU - Duerr, Susanne
AU - Wenning, Gregor K.
AU - Poewe, Werner
AU - Rubino, Alfonso
AU - Meco, Giuseppe
AU - Schneider, Susanne A.
AU - Bhatia, Kailash P.
AU - Djaldetti, Ruth
AU - Coelho, Miguel
AU - Sampaio, Cristina
AU - Cochen, Valerie
AU - Hellriegel, Helge
AU - Deuschl, Günther
AU - Colosimo, Carlo
AU - Marsili, Luca
AU - Gasser, Thomas
AU - Tolosa, Eduardo
PY - 2011/2
Y1 - 2011/2
N2 - Background: Sleep disorders are common in multiple system atrophy (MSA), but the prevalence of excessive daytime sleepiness (EDS) is not well known. Objective: To assess the frequency and associations of EDS in MSA. Design: Survey of EDS in consecutive patients with MSA and comparison with patients with Parkinson disease (PD) and individuals without known neurologic disease. Setting: Twelve tertiary referral centers. Participants: Eighty-six consecutive patients with MSA; 86 patients with PD matched for age, sex, and Hoehn and Yahr stage; and 86 healthy subject individuals matched for age and sex. Main Outcome Measures: Epworth Sleepiness Scale (ESS), modified ESS, Sudden Onset of Sleep Scale, Tandberg Sleepiness Scale, Pittsburgh Sleep Quality Index, disease severity, dopaminergic treatment amount, and presence of restless legs syndrome. Results: Mean (SD) ESS scores were comparable in MSA (7.72 [5.05]) and PD (8.23 [4.62]) but were higher than in healthy subjects (4.52 [2.98]) (P10) was present in 28% of patients with MSA, 29% of patients with PD, and 2% of healthy subjects (P
AB - Background: Sleep disorders are common in multiple system atrophy (MSA), but the prevalence of excessive daytime sleepiness (EDS) is not well known. Objective: To assess the frequency and associations of EDS in MSA. Design: Survey of EDS in consecutive patients with MSA and comparison with patients with Parkinson disease (PD) and individuals without known neurologic disease. Setting: Twelve tertiary referral centers. Participants: Eighty-six consecutive patients with MSA; 86 patients with PD matched for age, sex, and Hoehn and Yahr stage; and 86 healthy subject individuals matched for age and sex. Main Outcome Measures: Epworth Sleepiness Scale (ESS), modified ESS, Sudden Onset of Sleep Scale, Tandberg Sleepiness Scale, Pittsburgh Sleep Quality Index, disease severity, dopaminergic treatment amount, and presence of restless legs syndrome. Results: Mean (SD) ESS scores were comparable in MSA (7.72 [5.05]) and PD (8.23 [4.62]) but were higher than in healthy subjects (4.52 [2.98]) (P10) was present in 28% of patients with MSA, 29% of patients with PD, and 2% of healthy subjects (P
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U2 - 10.1001/archneurol.2010.359
DO - 10.1001/archneurol.2010.359
M3 - Article
C2 - 21320989
AN - SCOPUS:79951527045
VL - 68
SP - 223
EP - 230
JO - Archives of Neurology
JF - Archives of Neurology
SN - 0003-9942
IS - 2
ER -