Excessive daytime Sleepiness in Multiple System Atrophy (SLEEMSA study)

Claudia Moreno-López, Joan Santamaría, Manuel Salamero, Francesca Del Sorbo, Alberto Albanese, Maria Teresa Pellecchia, Paolo Barone, Sebastiaan Overeem, Bastiaan Bloem, Willemijn Aarden, Margherita Canesi, Angelo Antonini, Susanne Duerr, Gregor K. Wenning, Werner Poewe, Alfonso Rubino, Giuseppe Meco, Susanne A. Schneider, Kailash P. Bhatia, Ruth DjaldettiMiguel Coelho, Cristina Sampaio, Valerie Cochen, Helge Hellriegel, Günther Deuschl, Carlo Colosimo, Luca Marsili, Thomas Gasser, Eduardo Tolosa

Research output: Contribution to journalArticlepeer-review


Background: Sleep disorders are common in multiple system atrophy (MSA), but the prevalence of excessive daytime sleepiness (EDS) is not well known. Objective: To assess the frequency and associations of EDS in MSA. Design: Survey of EDS in consecutive patients with MSA and comparison with patients with Parkinson disease (PD) and individuals without known neurologic disease. Setting: Twelve tertiary referral centers. Participants: Eighty-six consecutive patients with MSA; 86 patients with PD matched for age, sex, and Hoehn and Yahr stage; and 86 healthy subject individuals matched for age and sex. Main Outcome Measures: Epworth Sleepiness Scale (ESS), modified ESS, Sudden Onset of Sleep Scale, Tandberg Sleepiness Scale, Pittsburgh Sleep Quality Index, disease severity, dopaminergic treatment amount, and presence of restless legs syndrome. Results: Mean (SD) ESS scores were comparable in MSA (7.72 [5.05]) and PD (8.23 [4.62]) but were higher than in healthy subjects (4.52 [2.98]) (P10) was present in 28% of patients with MSA, 29% of patients with PD, and 2% of healthy subjects (P

Original languageEnglish
Pages (from-to)223-230
Number of pages8
JournalArchives of Neurology
Issue number2
Publication statusPublished - Feb 2011

ASJC Scopus subject areas

  • Clinical Neurology


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