Excessive daytime Sleepiness in Multiple System Atrophy (SLEEMSA study)

Claudia Moreno-López; Joan Santamaría; Manuel Salamero; Francesca Del Sorbo; Alberto Albanese; Maria Teresa Pellecchia; Paolo Barone; Sebastiaan Overeem; Bastiaan Bloem; Willemijn Aarden; Margherita Canesi; Angelo Antonini; Susanne Duerr; Gregor K. Wenning; Werner Poewe; Alfonso Rubino; Giuseppe Meco; Susanne A. Schneider; Kailash P. Bhatia; Ruth Djaldetti; Miguel Coelho; Cristina Sampaio; Valerie Cochen; Helge Hellriegel; Günther Deuschl; Carlo Colosimo; Luca Marsili; Thomas Gasser; Eduardo Tolosa

doi:10.1001/archneurol.2010.359

Excessive daytime Sleepiness in Multiple System Atrophy (SLEEMSA study)

Claudia Moreno-López, Joan Santamaría, Manuel Salamero, Francesca Del Sorbo, Alberto Albanese, Maria Teresa Pellecchia, Paolo Barone, Sebastiaan Overeem, Bastiaan Bloem, Willemijn Aarden, Margherita Canesi, Angelo Antonini, Susanne Duerr, Gregor K. Wenning, Werner Poewe, Alfonso Rubino, Giuseppe Meco, Susanne A. Schneider, Kailash P. Bhatia, Ruth DjaldettiMiguel Coelho, Cristina Sampaio, Valerie Cochen, Helge Hellriegel, Günther Deuschl, Carlo Colosimo, Luca Marsili, Thomas Gasser, Eduardo Tolosa

Research output: Contribution to journal › Article › peer-review

Abstract

Background: Sleep disorders are common in multiple system atrophy (MSA), but the prevalence of excessive daytime sleepiness (EDS) is not well known. Objective: To assess the frequency and associations of EDS in MSA. Design: Survey of EDS in consecutive patients with MSA and comparison with patients with Parkinson disease (PD) and individuals without known neurologic disease. Setting: Twelve tertiary referral centers. Participants: Eighty-six consecutive patients with MSA; 86 patients with PD matched for age, sex, and Hoehn and Yahr stage; and 86 healthy subject individuals matched for age and sex. Main Outcome Measures: Epworth Sleepiness Scale (ESS), modified ESS, Sudden Onset of Sleep Scale, Tandberg Sleepiness Scale, Pittsburgh Sleep Quality Index, disease severity, dopaminergic treatment amount, and presence of restless legs syndrome. Results: Mean (SD) ESS scores were comparable in MSA (7.72 [5.05]) and PD (8.23 [4.62]) but were higher than in healthy subjects (4.52 [2.98]) (P10) was present in 28% of patients with MSA, 29% of patients with PD, and 2% of healthy subjects (P

Original language	English
Pages (from-to)	223-230
Number of pages	8
Journal	Archives of Neurology
Volume	68
Issue number	2
DOIs	https://doi.org/10.1001/archneurol.2010.359
Publication status	Published - Feb 2011

ASJC Scopus subject areas

Clinical Neurology

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Moreno-López, C., Santamaría, J., Salamero, M., Del Sorbo, F., Albanese, A., Pellecchia, M. T., Barone, P., Overeem, S., Bloem, B., Aarden, W., Canesi, M., Antonini, A., Duerr, S., Wenning, G. K., Poewe, W., Rubino, A., Meco, G., Schneider, S. A., Bhatia, K. P., ... Tolosa, E. (2011). Excessive daytime Sleepiness in Multiple System Atrophy (SLEEMSA study). Archives of Neurology, 68(2), 223-230. https://doi.org/10.1001/archneurol.2010.359

Moreno-López, C, Santamaría, J, Salamero, M, Del Sorbo, F, Albanese, A, Pellecchia, MT, Barone, P, Overeem, S, Bloem, B, Aarden, W, Canesi, M, Antonini, A, Duerr, S, Wenning, GK, Poewe, W, Rubino, A, Meco, G, Schneider, SA, Bhatia, KP, Djaldetti, R, Coelho, M, Sampaio, C, Cochen, V, Hellriegel, H, Deuschl, G, Colosimo, C, Marsili, L, Gasser, T & Tolosa, E 2011, 'Excessive daytime Sleepiness in Multiple System Atrophy (SLEEMSA study)', Archives of Neurology, vol. 68, no. 2, pp. 223-230. https://doi.org/10.1001/archneurol.2010.359

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title = "Excessive daytime Sleepiness in Multiple System Atrophy (SLEEMSA study)",

abstract = "Background: Sleep disorders are common in multiple system atrophy (MSA), but the prevalence of excessive daytime sleepiness (EDS) is not well known. Objective: To assess the frequency and associations of EDS in MSA. Design: Survey of EDS in consecutive patients with MSA and comparison with patients with Parkinson disease (PD) and individuals without known neurologic disease. Setting: Twelve tertiary referral centers. Participants: Eighty-six consecutive patients with MSA; 86 patients with PD matched for age, sex, and Hoehn and Yahr stage; and 86 healthy subject individuals matched for age and sex. Main Outcome Measures: Epworth Sleepiness Scale (ESS), modified ESS, Sudden Onset of Sleep Scale, Tandberg Sleepiness Scale, Pittsburgh Sleep Quality Index, disease severity, dopaminergic treatment amount, and presence of restless legs syndrome. Results: Mean (SD) ESS scores were comparable in MSA (7.72 [5.05]) and PD (8.23 [4.62]) but were higher than in healthy subjects (4.52 [2.98]) (P10) was present in 28% of patients with MSA, 29% of patients with PD, and 2% of healthy subjects (P",

author = "Claudia Moreno-L{\'o}pez and Joan Santamar{\'i}a and Manuel Salamero and {Del Sorbo}, Francesca and Alberto Albanese and Pellecchia, {Maria Teresa} and Paolo Barone and Sebastiaan Overeem and Bastiaan Bloem and Willemijn Aarden and Margherita Canesi and Angelo Antonini and Susanne Duerr and Wenning, {Gregor K.} and Werner Poewe and Alfonso Rubino and Giuseppe Meco and Schneider, {Susanne A.} and Bhatia, {Kailash P.} and Ruth Djaldetti and Miguel Coelho and Cristina Sampaio and Valerie Cochen and Helge Hellriegel and G{\"u}nther Deuschl and Carlo Colosimo and Luca Marsili and Thomas Gasser and Eduardo Tolosa",

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doi = "10.1001/archneurol.2010.359",

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T1 - Excessive daytime Sleepiness in Multiple System Atrophy (SLEEMSA study)

AU - Moreno-López, Claudia

AU - Santamaría, Joan

AU - Salamero, Manuel

AU - Del Sorbo, Francesca

AU - Albanese, Alberto

AU - Pellecchia, Maria Teresa

AU - Barone, Paolo

AU - Overeem, Sebastiaan

AU - Bloem, Bastiaan

AU - Aarden, Willemijn

AU - Canesi, Margherita

AU - Antonini, Angelo

AU - Duerr, Susanne

AU - Wenning, Gregor K.

AU - Poewe, Werner

AU - Rubino, Alfonso

AU - Meco, Giuseppe

AU - Schneider, Susanne A.

AU - Bhatia, Kailash P.

AU - Djaldetti, Ruth

AU - Coelho, Miguel

AU - Sampaio, Cristina

AU - Cochen, Valerie

AU - Hellriegel, Helge

AU - Deuschl, Günther

AU - Colosimo, Carlo

AU - Marsili, Luca

AU - Gasser, Thomas

AU - Tolosa, Eduardo

PY - 2011/2

Y1 - 2011/2

N2 - Background: Sleep disorders are common in multiple system atrophy (MSA), but the prevalence of excessive daytime sleepiness (EDS) is not well known. Objective: To assess the frequency and associations of EDS in MSA. Design: Survey of EDS in consecutive patients with MSA and comparison with patients with Parkinson disease (PD) and individuals without known neurologic disease. Setting: Twelve tertiary referral centers. Participants: Eighty-six consecutive patients with MSA; 86 patients with PD matched for age, sex, and Hoehn and Yahr stage; and 86 healthy subject individuals matched for age and sex. Main Outcome Measures: Epworth Sleepiness Scale (ESS), modified ESS, Sudden Onset of Sleep Scale, Tandberg Sleepiness Scale, Pittsburgh Sleep Quality Index, disease severity, dopaminergic treatment amount, and presence of restless legs syndrome. Results: Mean (SD) ESS scores were comparable in MSA (7.72 [5.05]) and PD (8.23 [4.62]) but were higher than in healthy subjects (4.52 [2.98]) (P10) was present in 28% of patients with MSA, 29% of patients with PD, and 2% of healthy subjects (P

AB - Background: Sleep disorders are common in multiple system atrophy (MSA), but the prevalence of excessive daytime sleepiness (EDS) is not well known. Objective: To assess the frequency and associations of EDS in MSA. Design: Survey of EDS in consecutive patients with MSA and comparison with patients with Parkinson disease (PD) and individuals without known neurologic disease. Setting: Twelve tertiary referral centers. Participants: Eighty-six consecutive patients with MSA; 86 patients with PD matched for age, sex, and Hoehn and Yahr stage; and 86 healthy subject individuals matched for age and sex. Main Outcome Measures: Epworth Sleepiness Scale (ESS), modified ESS, Sudden Onset of Sleep Scale, Tandberg Sleepiness Scale, Pittsburgh Sleep Quality Index, disease severity, dopaminergic treatment amount, and presence of restless legs syndrome. Results: Mean (SD) ESS scores were comparable in MSA (7.72 [5.05]) and PD (8.23 [4.62]) but were higher than in healthy subjects (4.52 [2.98]) (P10) was present in 28% of patients with MSA, 29% of patients with PD, and 2% of healthy subjects (P

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ER -

Excessive daytime Sleepiness in Multiple System Atrophy (SLEEMSA study)

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