Abstract
Congestive heart failure is characterized by sympathetic activation, which has also been described in the metabolic syndrome. No information exists, however, as to whether the sympathostimulating effects of these 2 conditions summate when heart failure is complicated by the metabolic syndrome, leading to an exceedingly high adrenergic drive. This is clinically relevant, because in heart failure sympathetic activation is closely related to mortality. We studied 48 control subjects (age: 58.4±1.6 years, mean±SEM) and 89 age-matched heart failure patients (New York Heart Association class II), of whom 47 were without and 42 were with metabolic syndrome. Measurements included blood pressure (Finapres), heart rate (ECG), and sympathetic nerve traffic (microneurography) at rest and during baroreceptor manipulation. Waist circumference, blood pressure, and metabolic variables were greater in heart failure with metabolic syndrome than in heart failure without metabolic syndrome and in control subjects. Left ventricular ejection fraction and end-diastolic diameter were similarly altered in the 2 heart failure groups. Compared with control subjects, sympathetic nerve activity was greater in heart failure patients without metabolic syndrome (64.7±3.2 versus 45.8±2.9 bursts/100 heartbeats; P
| Original language | English |
|---|---|
| Pages (from-to) | 535-541 |
| Number of pages | 7 |
| Journal | Hypertension |
| Volume | 49 |
| Issue number | 3 |
| DOIs | |
| Publication status | Published - Mar 2007 |
Fingerprint
Keywords
- Baroreflex
- Heart failure
- Metabolic syndrome
- Sympathetic nervous system
ASJC Scopus subject areas
- Internal Medicine
Cite this
Excessive sympathetic activation in heart failure with obesity and metabolic syndrome : Characteristics and mechanisms. / Grassi, Guido; Seravalle, Gino; Quarti-Trevano, Fosca; Scopelliti, Francesco; Dell'Oro, Raffaella; Bolla, Gianbattista; Mancia, Giuseppe.
In: Hypertension, Vol. 49, No. 3, 03.2007, p. 535-541.Research output: Contribution to journal › Article
}
TY - JOUR
T1 - Excessive sympathetic activation in heart failure with obesity and metabolic syndrome
T2 - Characteristics and mechanisms
AU - Grassi, Guido
AU - Seravalle, Gino
AU - Quarti-Trevano, Fosca
AU - Scopelliti, Francesco
AU - Dell'Oro, Raffaella
AU - Bolla, Gianbattista
AU - Mancia, Giuseppe
PY - 2007/3
Y1 - 2007/3
N2 - Congestive heart failure is characterized by sympathetic activation, which has also been described in the metabolic syndrome. No information exists, however, as to whether the sympathostimulating effects of these 2 conditions summate when heart failure is complicated by the metabolic syndrome, leading to an exceedingly high adrenergic drive. This is clinically relevant, because in heart failure sympathetic activation is closely related to mortality. We studied 48 control subjects (age: 58.4±1.6 years, mean±SEM) and 89 age-matched heart failure patients (New York Heart Association class II), of whom 47 were without and 42 were with metabolic syndrome. Measurements included blood pressure (Finapres), heart rate (ECG), and sympathetic nerve traffic (microneurography) at rest and during baroreceptor manipulation. Waist circumference, blood pressure, and metabolic variables were greater in heart failure with metabolic syndrome than in heart failure without metabolic syndrome and in control subjects. Left ventricular ejection fraction and end-diastolic diameter were similarly altered in the 2 heart failure groups. Compared with control subjects, sympathetic nerve activity was greater in heart failure patients without metabolic syndrome (64.7±3.2 versus 45.8±2.9 bursts/100 heartbeats; P
AB - Congestive heart failure is characterized by sympathetic activation, which has also been described in the metabolic syndrome. No information exists, however, as to whether the sympathostimulating effects of these 2 conditions summate when heart failure is complicated by the metabolic syndrome, leading to an exceedingly high adrenergic drive. This is clinically relevant, because in heart failure sympathetic activation is closely related to mortality. We studied 48 control subjects (age: 58.4±1.6 years, mean±SEM) and 89 age-matched heart failure patients (New York Heart Association class II), of whom 47 were without and 42 were with metabolic syndrome. Measurements included blood pressure (Finapres), heart rate (ECG), and sympathetic nerve traffic (microneurography) at rest and during baroreceptor manipulation. Waist circumference, blood pressure, and metabolic variables were greater in heart failure with metabolic syndrome than in heart failure without metabolic syndrome and in control subjects. Left ventricular ejection fraction and end-diastolic diameter were similarly altered in the 2 heart failure groups. Compared with control subjects, sympathetic nerve activity was greater in heart failure patients without metabolic syndrome (64.7±3.2 versus 45.8±2.9 bursts/100 heartbeats; P
KW - Baroreflex
KW - Heart failure
KW - Metabolic syndrome
KW - Sympathetic nervous system
UR - http://www.scopus.com/inward/record.url?scp=33847029977&partnerID=8YFLogxK
UR - http://www.scopus.com/inward/citedby.url?scp=33847029977&partnerID=8YFLogxK
U2 - 10.1161/01.HYP.0000255983.32896.b9
DO - 10.1161/01.HYP.0000255983.32896.b9
M3 - Article
VL - 49
SP - 535
EP - 541
JO - Hypertension
JF - Hypertension
SN - 0194-911X
IS - 3
ER -