Excisional cone as fertility-sparing treatment in early-stage cervical cancer

Anna Fagotti, Maria Lucia Gagliardi, Cristina Moruzzi, Vito Carone, Giovanni Scambia, Francesco Fanfani

Research output: Contribution to journalArticle

37 Citations (Scopus)

Abstract

Objective: To describe a case series of early-stage cervical cancer patients treated with excisional cone instead of radical trachelectomy as fertility-sparing surgery. Design: Prospective study. Setting: University hospital. Patient(s): Early-stage cervical cancer (International Federation of Gynecology and Obstetrics stage IA2-IB1), age ≤45 years, tumor ≤20 mm. Intervention(s): Cold-knife conization and laparoscopic pelvic lymphadenectomy. Main Outcome Measure(s): Recurrence and pregnancy rate. Result(s): There were 17 patients: 4 (23.5%) IA2, 13 (76.5%) IB1; 12 (70.5%) squamous cell carcinoma, 4 (23.5%) adenocarcinoma, and 1 (6%) glassy cell tumor. Four cases (23.5%) involved lymphovascular space invasion. The median number of lymph nodes removed was 18 (range 13-51). None of the patients received neoadjuvant chemotherapy, and two patients (12%) received three courses of adjuvant chemotherapy. No recurrences were observed after a median follow-up of 16 months (range 8-101 months). Two of five patients (40%) attempting to conceive had a spontaneous pregnancy and delivery. Conclusion(s): In selected and informed patients, conization and laparoscopic pelvic lymphadenectomy seems to be feasible as a fertility-sparing surgical approach.

Original languageEnglish
Pages (from-to)1109-1112
Number of pages4
JournalFertility and Sterility
Volume95
Issue number3
DOIs
Publication statusPublished - Mar 1 2011

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Uterine Cervical Neoplasms
Fertility
Conization
Lymph Node Excision
Therapeutics
Recurrence
Pregnancy Rate
Adjuvant Chemotherapy
Gynecology
Obstetrics
Squamous Cell Carcinoma
Neoplasms
Adenocarcinoma
Lymph Nodes
Outcome Assessment (Health Care)
Prospective Studies
Drug Therapy
Pregnancy

Keywords

  • Cervical cancer
  • conization
  • fertility-sparing
  • pelvic lymphadenectomy

ASJC Scopus subject areas

  • Obstetrics and Gynaecology
  • Reproductive Medicine

Cite this

Fagotti, A., Gagliardi, M. L., Moruzzi, C., Carone, V., Scambia, G., & Fanfani, F. (2011). Excisional cone as fertility-sparing treatment in early-stage cervical cancer. Fertility and Sterility, 95(3), 1109-1112. https://doi.org/10.1016/j.fertnstert.2010.11.010

Excisional cone as fertility-sparing treatment in early-stage cervical cancer. / Fagotti, Anna; Gagliardi, Maria Lucia; Moruzzi, Cristina; Carone, Vito; Scambia, Giovanni; Fanfani, Francesco.

In: Fertility and Sterility, Vol. 95, No. 3, 01.03.2011, p. 1109-1112.

Research output: Contribution to journalArticle

Fagotti, A, Gagliardi, ML, Moruzzi, C, Carone, V, Scambia, G & Fanfani, F 2011, 'Excisional cone as fertility-sparing treatment in early-stage cervical cancer', Fertility and Sterility, vol. 95, no. 3, pp. 1109-1112. https://doi.org/10.1016/j.fertnstert.2010.11.010
Fagotti A, Gagliardi ML, Moruzzi C, Carone V, Scambia G, Fanfani F. Excisional cone as fertility-sparing treatment in early-stage cervical cancer. Fertility and Sterility. 2011 Mar 1;95(3):1109-1112. https://doi.org/10.1016/j.fertnstert.2010.11.010
Fagotti, Anna ; Gagliardi, Maria Lucia ; Moruzzi, Cristina ; Carone, Vito ; Scambia, Giovanni ; Fanfani, Francesco. / Excisional cone as fertility-sparing treatment in early-stage cervical cancer. In: Fertility and Sterility. 2011 ; Vol. 95, No. 3. pp. 1109-1112.
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