Excitability of the motor cortex in de novo patients with celiac disease

Giovanni Pennisi, Giuseppe Lanza, Salvatore Giuffrida, Luisa Vinciguerra, Valentina Puglisi, Mariagiovanna Cantone, Manuela Pennisi, Carmela Cinzia D'Agate, Pietro Naso, Giuseppe Aprile, Giulia Malaguarnera, Raffaele Ferri, Rita Bella

Research output: Contribution to journalArticle

18 Citations (Scopus)

Abstract

Introduction: Celiac disease (CD) may initially present as a neurological disorder or may be complicated by neurological changes. To date, neurophysiological studies aiming to an objective evaluation of the potential central nervous system involvement in CD are lacking. Objective: To assess the profile of cortical excitability to Transcranial Magnetic Stimulation (TMS) in a group of de novo CD patients. Materials and methods: Twenty CD patients underwent a screening for cognitive and neuropsychiatric symptoms by means of the Mini Mental State Examination and the Structured Clinical Interview for DSM-IV Axis I Disorders, respectively. Instrumental exams, including electroencephalography and brain computed tomography, were also performed. Corticospinal excitability was assessed by means of single and paired-pulse TMS using the first dorsal interosseus muscle of the dominant hand. TMS measures consisted of resting motor threshold, motor evoked potentials, cortical silent period (CSP), intracortical inhibition (ICI) and facilitation (ICF). None of the CD was on gluten-free diet. A group of 20 age-matched healthy controls was used for comparisons. Results: CD showed a significantly shorter CSP (78.0 vs 125.0 ms, p

Original languageEnglish
Article numbere102790
JournalPLoS One
Volume9
Issue number7
DOIs
Publication statusPublished - Jul 25 2014

Fingerprint

celiac disease
Motor Cortex
Celiac Disease
Transcranial Magnetic Stimulation
gluten-free diet
Gluten-Free Diet
Motor Evoked Potentials
Neurobehavioral Manifestations
electroencephalography
evoked potentials
nervous system diseases
Glutens
Bioelectric potentials
Neurology
Nutrition
Electroencephalography
Nervous System Diseases
computed tomography
Diagnostic and Statistical Manual of Mental Disorders
signs and symptoms (animals and humans)

ASJC Scopus subject areas

  • Agricultural and Biological Sciences(all)
  • Biochemistry, Genetics and Molecular Biology(all)
  • Medicine(all)

Cite this

Pennisi, G., Lanza, G., Giuffrida, S., Vinciguerra, L., Puglisi, V., Cantone, M., ... Bella, R. (2014). Excitability of the motor cortex in de novo patients with celiac disease. PLoS One, 9(7), [e102790]. https://doi.org/10.1371/journal.pone.0102790

Excitability of the motor cortex in de novo patients with celiac disease. / Pennisi, Giovanni; Lanza, Giuseppe; Giuffrida, Salvatore; Vinciguerra, Luisa; Puglisi, Valentina; Cantone, Mariagiovanna; Pennisi, Manuela; D'Agate, Carmela Cinzia; Naso, Pietro; Aprile, Giuseppe; Malaguarnera, Giulia; Ferri, Raffaele; Bella, Rita.

In: PLoS One, Vol. 9, No. 7, e102790, 25.07.2014.

Research output: Contribution to journalArticle

Pennisi, G, Lanza, G, Giuffrida, S, Vinciguerra, L, Puglisi, V, Cantone, M, Pennisi, M, D'Agate, CC, Naso, P, Aprile, G, Malaguarnera, G, Ferri, R & Bella, R 2014, 'Excitability of the motor cortex in de novo patients with celiac disease', PLoS One, vol. 9, no. 7, e102790. https://doi.org/10.1371/journal.pone.0102790
Pennisi G, Lanza G, Giuffrida S, Vinciguerra L, Puglisi V, Cantone M et al. Excitability of the motor cortex in de novo patients with celiac disease. PLoS One. 2014 Jul 25;9(7). e102790. https://doi.org/10.1371/journal.pone.0102790
Pennisi, Giovanni ; Lanza, Giuseppe ; Giuffrida, Salvatore ; Vinciguerra, Luisa ; Puglisi, Valentina ; Cantone, Mariagiovanna ; Pennisi, Manuela ; D'Agate, Carmela Cinzia ; Naso, Pietro ; Aprile, Giuseppe ; Malaguarnera, Giulia ; Ferri, Raffaele ; Bella, Rita. / Excitability of the motor cortex in de novo patients with celiac disease. In: PLoS One. 2014 ; Vol. 9, No. 7.
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