Abstract
Introduction: Celiac disease (CD) may initially present as a neurological disorder or may be complicated by neurological changes. To date, neurophysiological studies aiming to an objective evaluation of the potential central nervous system involvement in CD are lacking. Objective: To assess the profile of cortical excitability to Transcranial Magnetic Stimulation (TMS) in a group of de novo CD patients. Materials and methods: Twenty CD patients underwent a screening for cognitive and neuropsychiatric symptoms by means of the Mini Mental State Examination and the Structured Clinical Interview for DSM-IV Axis I Disorders, respectively. Instrumental exams, including electroencephalography and brain computed tomography, were also performed. Corticospinal excitability was assessed by means of single and paired-pulse TMS using the first dorsal interosseus muscle of the dominant hand. TMS measures consisted of resting motor threshold, motor evoked potentials, cortical silent period (CSP), intracortical inhibition (ICI) and facilitation (ICF). None of the CD was on gluten-free diet. A group of 20 age-matched healthy controls was used for comparisons. Results: CD showed a significantly shorter CSP (78.0 vs 125.0 ms, p
| Original language | English |
|---|---|
| Article number | e102790 |
| Journal | PLoS One |
| Volume | 9 |
| Issue number | 7 |
| DOIs | |
| Publication status | Published - Jul 25 2014 |
Fingerprint
ASJC Scopus subject areas
- Agricultural and Biological Sciences(all)
- Biochemistry, Genetics and Molecular Biology(all)
- Medicine(all)
Cite this
Excitability of the motor cortex in de novo patients with celiac disease. / Pennisi, Giovanni; Lanza, Giuseppe; Giuffrida, Salvatore; Vinciguerra, Luisa; Puglisi, Valentina; Cantone, Mariagiovanna; Pennisi, Manuela; D'Agate, Carmela Cinzia; Naso, Pietro; Aprile, Giuseppe; Malaguarnera, Giulia; Ferri, Raffaele; Bella, Rita.
In: PLoS One, Vol. 9, No. 7, e102790, 25.07.2014.Research output: Contribution to journal › Article
}
TY - JOUR
T1 - Excitability of the motor cortex in de novo patients with celiac disease
AU - Pennisi, Giovanni
AU - Lanza, Giuseppe
AU - Giuffrida, Salvatore
AU - Vinciguerra, Luisa
AU - Puglisi, Valentina
AU - Cantone, Mariagiovanna
AU - Pennisi, Manuela
AU - D'Agate, Carmela Cinzia
AU - Naso, Pietro
AU - Aprile, Giuseppe
AU - Malaguarnera, Giulia
AU - Ferri, Raffaele
AU - Bella, Rita
PY - 2014/7/25
Y1 - 2014/7/25
N2 - Introduction: Celiac disease (CD) may initially present as a neurological disorder or may be complicated by neurological changes. To date, neurophysiological studies aiming to an objective evaluation of the potential central nervous system involvement in CD are lacking. Objective: To assess the profile of cortical excitability to Transcranial Magnetic Stimulation (TMS) in a group of de novo CD patients. Materials and methods: Twenty CD patients underwent a screening for cognitive and neuropsychiatric symptoms by means of the Mini Mental State Examination and the Structured Clinical Interview for DSM-IV Axis I Disorders, respectively. Instrumental exams, including electroencephalography and brain computed tomography, were also performed. Corticospinal excitability was assessed by means of single and paired-pulse TMS using the first dorsal interosseus muscle of the dominant hand. TMS measures consisted of resting motor threshold, motor evoked potentials, cortical silent period (CSP), intracortical inhibition (ICI) and facilitation (ICF). None of the CD was on gluten-free diet. A group of 20 age-matched healthy controls was used for comparisons. Results: CD showed a significantly shorter CSP (78.0 vs 125.0 ms, p
AB - Introduction: Celiac disease (CD) may initially present as a neurological disorder or may be complicated by neurological changes. To date, neurophysiological studies aiming to an objective evaluation of the potential central nervous system involvement in CD are lacking. Objective: To assess the profile of cortical excitability to Transcranial Magnetic Stimulation (TMS) in a group of de novo CD patients. Materials and methods: Twenty CD patients underwent a screening for cognitive and neuropsychiatric symptoms by means of the Mini Mental State Examination and the Structured Clinical Interview for DSM-IV Axis I Disorders, respectively. Instrumental exams, including electroencephalography and brain computed tomography, were also performed. Corticospinal excitability was assessed by means of single and paired-pulse TMS using the first dorsal interosseus muscle of the dominant hand. TMS measures consisted of resting motor threshold, motor evoked potentials, cortical silent period (CSP), intracortical inhibition (ICI) and facilitation (ICF). None of the CD was on gluten-free diet. A group of 20 age-matched healthy controls was used for comparisons. Results: CD showed a significantly shorter CSP (78.0 vs 125.0 ms, p
UR - http://www.scopus.com/inward/record.url?scp=84904866508&partnerID=8YFLogxK
UR - http://www.scopus.com/inward/citedby.url?scp=84904866508&partnerID=8YFLogxK
U2 - 10.1371/journal.pone.0102790
DO - 10.1371/journal.pone.0102790
M3 - Article
VL - 9
JO - PLoS One
JF - PLoS One
SN - 1932-6203
IS - 7
M1 - e102790
ER -