Exclusion of CARD15/NOD2 as a candidate susceptibility gene to psoriasis in the Italian population

Paola Borgiani, Laura Vallo, Maria Rosaria D'Apice, Emiliano Giardina, Sabina Pucci, Francesca Capon, Steven Nisticò, Sergio Chimenti, Francesco Pallone, Giuseppe Novelli

Research output: Contribution to journalArticlepeer-review

Abstract

Psoriasis is a chronic inflammatory skin disorder showing multifactorial inheritance. Linkage studies have mapped disease susceptibility loci to several genomic regions, including the chromosome 16 interval that contains the CARD15/NOD2 gene. CARD15 has been involved in Crohn's Disease (CD) susceptibility and it has been hypothesised that it may also contribute to the pathogenesis of psoriasis. To test this hypothesis we studied the distribution of 3 CARD15 SNPs in an Italian case-control data set. We failed to observe any significant difference between patients and controls, thereby excluding the presence of a strong genetic association between CARD15 gene polymorphisms and psoriasis, in the Italian population.

Original languageEnglish
Pages (from-to)540-542
Number of pages3
JournalEuropean Journal of Dermatology
Volume12
Issue number6
Publication statusPublished - Nov 2002

Keywords

  • CARD15
  • Crohn's Disease
  • Genetic susceptibility
  • NOD2
  • Psoriasis
  • Pyrosequencing

ASJC Scopus subject areas

  • Dermatology

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