Abstract
Infection with human polyomaviruses BKV and JCVis asymptomatic, and lifelong andwidespread, among the general population. However, in the settingof immunosuppression,secondary tomedications or viral infection, for example, with HIV, reactivation can occur and result in severe disease. In this study, stool specimens from 31 patients with hematological disorders (25 transplanted and 6 non-transplanted) were examined prospectively to determine whether the novel polyomaviruses KIV and WUV reactivated and were excreted in the gastrointestinal tract. Reactivation was correlated with the appearance of gastrointestinal and respiratory symptoms.Of the 31 patients examined, KIV andWUVwere detected in 13 transplanted patients as single infection or in combination with BKV, cytomegalovirus (CMV), and adenovirus (Adv). Because of frequent co-infections, a clear correlation between novel polyomaviruses and clinical symptoms could not be established. There was no correlation between demographic variables and detection ofKIV andWUV. Phylogenetic analysis of the small t-antigen gene of KIV and WUV isolates showed that the novel polyomaviruses identified in feces clustered with those identified in the respiratory tract suggesting an oral-fecal transmission of these viruses. The novel polyomaviruses KI and WU may have a pathogenic role in immunocompromised patients.
| Original language | English |
|---|---|
| Pages (from-to) | 1668-1673 |
| Number of pages | 6 |
| Journal | Journal of Medical Virology |
| Volume | 81 |
| Issue number | 9 |
| DOIs | |
| Publication status | Published - Sep 2009 |
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Keywords
- Gastrointestinal symptoms
- Immunodeficiency
- Novel polyomaviruses
- Transplantation
- Viral reactivation
ASJC Scopus subject areas
- Virology
- Infectious Diseases
Cite this
Excretion of the novel polyomaviruses KI and WU in the stool of patients with hematological disorders. / Babakir-Mina, Muhammed; Ciccozzi, Massimo; Alteri, Claudia; Polchi, Paola; Picardi, Alessandra; Greco, Francesco; Lucarelli, Guido; Arcese, William; Perno, Carlo Federico; Ciotti, Marco.
In: Journal of Medical Virology, Vol. 81, No. 9, 09.2009, p. 1668-1673.Research output: Contribution to journal › Article
}
TY - JOUR
T1 - Excretion of the novel polyomaviruses KI and WU in the stool of patients with hematological disorders
AU - Babakir-Mina, Muhammed
AU - Ciccozzi, Massimo
AU - Alteri, Claudia
AU - Polchi, Paola
AU - Picardi, Alessandra
AU - Greco, Francesco
AU - Lucarelli, Guido
AU - Arcese, William
AU - Perno, Carlo Federico
AU - Ciotti, Marco
PY - 2009/9
Y1 - 2009/9
N2 - Infection with human polyomaviruses BKV and JCVis asymptomatic, and lifelong andwidespread, among the general population. However, in the settingof immunosuppression,secondary tomedications or viral infection, for example, with HIV, reactivation can occur and result in severe disease. In this study, stool specimens from 31 patients with hematological disorders (25 transplanted and 6 non-transplanted) were examined prospectively to determine whether the novel polyomaviruses KIV and WUV reactivated and were excreted in the gastrointestinal tract. Reactivation was correlated with the appearance of gastrointestinal and respiratory symptoms.Of the 31 patients examined, KIV andWUVwere detected in 13 transplanted patients as single infection or in combination with BKV, cytomegalovirus (CMV), and adenovirus (Adv). Because of frequent co-infections, a clear correlation between novel polyomaviruses and clinical symptoms could not be established. There was no correlation between demographic variables and detection ofKIV andWUV. Phylogenetic analysis of the small t-antigen gene of KIV and WUV isolates showed that the novel polyomaviruses identified in feces clustered with those identified in the respiratory tract suggesting an oral-fecal transmission of these viruses. The novel polyomaviruses KI and WU may have a pathogenic role in immunocompromised patients.
AB - Infection with human polyomaviruses BKV and JCVis asymptomatic, and lifelong andwidespread, among the general population. However, in the settingof immunosuppression,secondary tomedications or viral infection, for example, with HIV, reactivation can occur and result in severe disease. In this study, stool specimens from 31 patients with hematological disorders (25 transplanted and 6 non-transplanted) were examined prospectively to determine whether the novel polyomaviruses KIV and WUV reactivated and were excreted in the gastrointestinal tract. Reactivation was correlated with the appearance of gastrointestinal and respiratory symptoms.Of the 31 patients examined, KIV andWUVwere detected in 13 transplanted patients as single infection or in combination with BKV, cytomegalovirus (CMV), and adenovirus (Adv). Because of frequent co-infections, a clear correlation between novel polyomaviruses and clinical symptoms could not be established. There was no correlation between demographic variables and detection ofKIV andWUV. Phylogenetic analysis of the small t-antigen gene of KIV and WUV isolates showed that the novel polyomaviruses identified in feces clustered with those identified in the respiratory tract suggesting an oral-fecal transmission of these viruses. The novel polyomaviruses KI and WU may have a pathogenic role in immunocompromised patients.
KW - Gastrointestinal symptoms
KW - Immunodeficiency
KW - Novel polyomaviruses
KW - Transplantation
KW - Viral reactivation
UR - http://www.scopus.com/inward/record.url?scp=68049096755&partnerID=8YFLogxK
UR - http://www.scopus.com/inward/citedby.url?scp=68049096755&partnerID=8YFLogxK
U2 - 10.1002/jmv.21559
DO - 10.1002/jmv.21559
M3 - Article
C2 - 19626610
AN - SCOPUS:68049096755
VL - 81
SP - 1668
EP - 1673
JO - Journal of Medical Virology
JF - Journal of Medical Virology
SN - 0146-6615
IS - 9
ER -