Excretion of the novel polyomaviruses KI and WU in the stool of patients with hematological disorders

Muhammed Babakir-Mina, Massimo Ciccozzi, Claudia Alteri, Paola Polchi, Alessandra Picardi, Francesco Greco, Guido Lucarelli, William Arcese, Carlo Federico Perno, Marco Ciotti

Research output: Contribution to journalArticle

37 Citations (Scopus)

Abstract

Infection with human polyomaviruses BKV and JCVis asymptomatic, and lifelong andwidespread, among the general population. However, in the settingof immunosuppression,secondary tomedications or viral infection, for example, with HIV, reactivation can occur and result in severe disease. In this study, stool specimens from 31 patients with hematological disorders (25 transplanted and 6 non-transplanted) were examined prospectively to determine whether the novel polyomaviruses KIV and WUV reactivated and were excreted in the gastrointestinal tract. Reactivation was correlated with the appearance of gastrointestinal and respiratory symptoms.Of the 31 patients examined, KIV andWUVwere detected in 13 transplanted patients as single infection or in combination with BKV, cytomegalovirus (CMV), and adenovirus (Adv). Because of frequent co-infections, a clear correlation between novel polyomaviruses and clinical symptoms could not be established. There was no correlation between demographic variables and detection ofKIV andWUV. Phylogenetic analysis of the small t-antigen gene of KIV and WUV isolates showed that the novel polyomaviruses identified in feces clustered with those identified in the respiratory tract suggesting an oral-fecal transmission of these viruses. The novel polyomaviruses KI and WU may have a pathogenic role in immunocompromised patients.

Original languageEnglish
Pages (from-to)1668-1673
Number of pages6
JournalJournal of Medical Virology
Volume81
Issue number9
DOIs
Publication statusPublished - Sep 2009

Fingerprint

Polyomavirus
Coinfection
Immunocompromised Host
Virus Diseases
Infection
Cytomegalovirus
Adenoviridae
Feces
Respiratory System
Immunosuppression
Gastrointestinal Tract
Demography
HIV
Viruses
Antigens
Population
Genes

Keywords

  • Gastrointestinal symptoms
  • Immunodeficiency
  • Novel polyomaviruses
  • Transplantation
  • Viral reactivation

ASJC Scopus subject areas

  • Virology
  • Infectious Diseases

Cite this

Babakir-Mina, M., Ciccozzi, M., Alteri, C., Polchi, P., Picardi, A., Greco, F., ... Ciotti, M. (2009). Excretion of the novel polyomaviruses KI and WU in the stool of patients with hematological disorders. Journal of Medical Virology, 81(9), 1668-1673. https://doi.org/10.1002/jmv.21559

Excretion of the novel polyomaviruses KI and WU in the stool of patients with hematological disorders. / Babakir-Mina, Muhammed; Ciccozzi, Massimo; Alteri, Claudia; Polchi, Paola; Picardi, Alessandra; Greco, Francesco; Lucarelli, Guido; Arcese, William; Perno, Carlo Federico; Ciotti, Marco.

In: Journal of Medical Virology, Vol. 81, No. 9, 09.2009, p. 1668-1673.

Research output: Contribution to journalArticle

Babakir-Mina, M, Ciccozzi, M, Alteri, C, Polchi, P, Picardi, A, Greco, F, Lucarelli, G, Arcese, W, Perno, CF & Ciotti, M 2009, 'Excretion of the novel polyomaviruses KI and WU in the stool of patients with hematological disorders', Journal of Medical Virology, vol. 81, no. 9, pp. 1668-1673. https://doi.org/10.1002/jmv.21559
Babakir-Mina, Muhammed ; Ciccozzi, Massimo ; Alteri, Claudia ; Polchi, Paola ; Picardi, Alessandra ; Greco, Francesco ; Lucarelli, Guido ; Arcese, William ; Perno, Carlo Federico ; Ciotti, Marco. / Excretion of the novel polyomaviruses KI and WU in the stool of patients with hematological disorders. In: Journal of Medical Virology. 2009 ; Vol. 81, No. 9. pp. 1668-1673.
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