Executive Dysfunction Detected with the Frontal Assessment Battery in Alzheimer's Disease Versus Vascular Dementia

Grazia D'Onofrio, Francesco Panza, Daniele Sancarlo, Filomena Addante, Vincenzo Solfrizzi, Chiara Cantarini, Antonio Mangiacotti, Michele Lauriola, Leandro Cascavilla, Francesco Paris, Madia Lozupone, Antonio Daniele, Antonio Greco, Davide Seripa

Research output: Contribution to journalArticle

Abstract

Alzheimer's disease (AD) and vascular dementia (VaD) lead to progressive decline in executive function. We estimated the prevalence of executive dysfunction in AD and VaD patients, investigating cognitive, functional, and clinical correlates and also using a multidimensional approach based on a standardized comprehensive geriatric assessment (CGA). We included 215 patients (115 AD patients and 100 VaD patients) consecutively evaluated with a complete cognitive and affective assessment, a CGA, and the Frontal Assessment Battery (FAB) with six subtests investigating conceptualization, mental flexibility, motor programming, sensitivity to interference, inhibitory control, and environmental autonomy. The prevalence of dysexecutive syndrome screened with a FAB score <12 points was high in both AD (97 patients) and VaD (77 patients) (84.3% versus 77.0%, p = 0.171). AD patients were significantly younger, with higher grade of cognitive impairment and less severe comorbidity and polypharmacy than VaD patients. AD patients showed a significantly higher impairment in FAB total score and five FAB subtests (conceptualization, motor programming, sensitivity to interference, inhibitory control, and environmental autonomy) than VaD patients. These findings were largely confirmed in a sub-analysis conducted subdividing the sample in mild and moderate-to-severe demented patients and suggesting that in moderate-to-severe AD there was higher impairment in FAB total score and four FAB subtests (conceptualization, sensitivity to interference, inhibitory control, and environmental autonomy). Executive dysfunction could be greater in AD patients with moderate-to-severe dementia compared to VaD patients, although our groups were also not matched for age, comorbidity or polypharmacy, which could also exert an effect.

Original languageEnglish
Pages (from-to)699-711
Number of pages13
JournalJournal of Alzheimer's Disease
Volume62
Issue number2
DOIs
Publication statusPublished - Jan 1 2018

Fingerprint

Vascular Dementia
Alzheimer Disease
Geriatric Assessment
Polypharmacy
Comorbidity
Executive Function
Dementia

Keywords

  • Alzheimer's disease
  • comprehensive geriatric assessment
  • dementia
  • executive function
  • vascular dementia

ASJC Scopus subject areas

  • Neuroscience(all)
  • Clinical Psychology
  • Geriatrics and Gerontology
  • Psychiatry and Mental health

Cite this

Executive Dysfunction Detected with the Frontal Assessment Battery in Alzheimer's Disease Versus Vascular Dementia. / D'Onofrio, Grazia; Panza, Francesco; Sancarlo, Daniele; Addante, Filomena; Solfrizzi, Vincenzo; Cantarini, Chiara; Mangiacotti, Antonio; Lauriola, Michele; Cascavilla, Leandro; Paris, Francesco; Lozupone, Madia; Daniele, Antonio; Greco, Antonio; Seripa, Davide.

In: Journal of Alzheimer's Disease, Vol. 62, No. 2, 01.01.2018, p. 699-711.

Research output: Contribution to journalArticle

D'Onofrio, G, Panza, F, Sancarlo, D, Addante, F, Solfrizzi, V, Cantarini, C, Mangiacotti, A, Lauriola, M, Cascavilla, L, Paris, F, Lozupone, M, Daniele, A, Greco, A & Seripa, D 2018, 'Executive Dysfunction Detected with the Frontal Assessment Battery in Alzheimer's Disease Versus Vascular Dementia', Journal of Alzheimer's Disease, vol. 62, no. 2, pp. 699-711. https://doi.org/10.3233/JAD-170365
D'Onofrio, Grazia ; Panza, Francesco ; Sancarlo, Daniele ; Addante, Filomena ; Solfrizzi, Vincenzo ; Cantarini, Chiara ; Mangiacotti, Antonio ; Lauriola, Michele ; Cascavilla, Leandro ; Paris, Francesco ; Lozupone, Madia ; Daniele, Antonio ; Greco, Antonio ; Seripa, Davide. / Executive Dysfunction Detected with the Frontal Assessment Battery in Alzheimer's Disease Versus Vascular Dementia. In: Journal of Alzheimer's Disease. 2018 ; Vol. 62, No. 2. pp. 699-711.
@article{4fa94493263d4e86a40e5eb688143c8f,
title = "Executive Dysfunction Detected with the Frontal Assessment Battery in Alzheimer's Disease Versus Vascular Dementia",
abstract = "Alzheimer's disease (AD) and vascular dementia (VaD) lead to progressive decline in executive function. We estimated the prevalence of executive dysfunction in AD and VaD patients, investigating cognitive, functional, and clinical correlates and also using a multidimensional approach based on a standardized comprehensive geriatric assessment (CGA). We included 215 patients (115 AD patients and 100 VaD patients) consecutively evaluated with a complete cognitive and affective assessment, a CGA, and the Frontal Assessment Battery (FAB) with six subtests investigating conceptualization, mental flexibility, motor programming, sensitivity to interference, inhibitory control, and environmental autonomy. The prevalence of dysexecutive syndrome screened with a FAB score <12 points was high in both AD (97 patients) and VaD (77 patients) (84.3{\%} versus 77.0{\%}, p = 0.171). AD patients were significantly younger, with higher grade of cognitive impairment and less severe comorbidity and polypharmacy than VaD patients. AD patients showed a significantly higher impairment in FAB total score and five FAB subtests (conceptualization, motor programming, sensitivity to interference, inhibitory control, and environmental autonomy) than VaD patients. These findings were largely confirmed in a sub-analysis conducted subdividing the sample in mild and moderate-to-severe demented patients and suggesting that in moderate-to-severe AD there was higher impairment in FAB total score and four FAB subtests (conceptualization, sensitivity to interference, inhibitory control, and environmental autonomy). Executive dysfunction could be greater in AD patients with moderate-to-severe dementia compared to VaD patients, although our groups were also not matched for age, comorbidity or polypharmacy, which could also exert an effect.",
keywords = "Alzheimer's disease, comprehensive geriatric assessment, dementia, executive function, vascular dementia",
author = "Grazia D'Onofrio and Francesco Panza and Daniele Sancarlo and Filomena Addante and Vincenzo Solfrizzi and Chiara Cantarini and Antonio Mangiacotti and Michele Lauriola and Leandro Cascavilla and Francesco Paris and Madia Lozupone and Antonio Daniele and Antonio Greco and Davide Seripa",
year = "2018",
month = "1",
day = "1",
doi = "10.3233/JAD-170365",
language = "English",
volume = "62",
pages = "699--711",
journal = "Journal of Alzheimer's Disease",
issn = "1387-2877",
publisher = "IOS Press",
number = "2",

}

TY - JOUR

T1 - Executive Dysfunction Detected with the Frontal Assessment Battery in Alzheimer's Disease Versus Vascular Dementia

AU - D'Onofrio, Grazia

AU - Panza, Francesco

AU - Sancarlo, Daniele

AU - Addante, Filomena

AU - Solfrizzi, Vincenzo

AU - Cantarini, Chiara

AU - Mangiacotti, Antonio

AU - Lauriola, Michele

AU - Cascavilla, Leandro

AU - Paris, Francesco

AU - Lozupone, Madia

AU - Daniele, Antonio

AU - Greco, Antonio

AU - Seripa, Davide

PY - 2018/1/1

Y1 - 2018/1/1

N2 - Alzheimer's disease (AD) and vascular dementia (VaD) lead to progressive decline in executive function. We estimated the prevalence of executive dysfunction in AD and VaD patients, investigating cognitive, functional, and clinical correlates and also using a multidimensional approach based on a standardized comprehensive geriatric assessment (CGA). We included 215 patients (115 AD patients and 100 VaD patients) consecutively evaluated with a complete cognitive and affective assessment, a CGA, and the Frontal Assessment Battery (FAB) with six subtests investigating conceptualization, mental flexibility, motor programming, sensitivity to interference, inhibitory control, and environmental autonomy. The prevalence of dysexecutive syndrome screened with a FAB score <12 points was high in both AD (97 patients) and VaD (77 patients) (84.3% versus 77.0%, p = 0.171). AD patients were significantly younger, with higher grade of cognitive impairment and less severe comorbidity and polypharmacy than VaD patients. AD patients showed a significantly higher impairment in FAB total score and five FAB subtests (conceptualization, motor programming, sensitivity to interference, inhibitory control, and environmental autonomy) than VaD patients. These findings were largely confirmed in a sub-analysis conducted subdividing the sample in mild and moderate-to-severe demented patients and suggesting that in moderate-to-severe AD there was higher impairment in FAB total score and four FAB subtests (conceptualization, sensitivity to interference, inhibitory control, and environmental autonomy). Executive dysfunction could be greater in AD patients with moderate-to-severe dementia compared to VaD patients, although our groups were also not matched for age, comorbidity or polypharmacy, which could also exert an effect.

AB - Alzheimer's disease (AD) and vascular dementia (VaD) lead to progressive decline in executive function. We estimated the prevalence of executive dysfunction in AD and VaD patients, investigating cognitive, functional, and clinical correlates and also using a multidimensional approach based on a standardized comprehensive geriatric assessment (CGA). We included 215 patients (115 AD patients and 100 VaD patients) consecutively evaluated with a complete cognitive and affective assessment, a CGA, and the Frontal Assessment Battery (FAB) with six subtests investigating conceptualization, mental flexibility, motor programming, sensitivity to interference, inhibitory control, and environmental autonomy. The prevalence of dysexecutive syndrome screened with a FAB score <12 points was high in both AD (97 patients) and VaD (77 patients) (84.3% versus 77.0%, p = 0.171). AD patients were significantly younger, with higher grade of cognitive impairment and less severe comorbidity and polypharmacy than VaD patients. AD patients showed a significantly higher impairment in FAB total score and five FAB subtests (conceptualization, motor programming, sensitivity to interference, inhibitory control, and environmental autonomy) than VaD patients. These findings were largely confirmed in a sub-analysis conducted subdividing the sample in mild and moderate-to-severe demented patients and suggesting that in moderate-to-severe AD there was higher impairment in FAB total score and four FAB subtests (conceptualization, sensitivity to interference, inhibitory control, and environmental autonomy). Executive dysfunction could be greater in AD patients with moderate-to-severe dementia compared to VaD patients, although our groups were also not matched for age, comorbidity or polypharmacy, which could also exert an effect.

KW - Alzheimer's disease

KW - comprehensive geriatric assessment

KW - dementia

KW - executive function

KW - vascular dementia

UR - http://www.scopus.com/inward/record.url?scp=85043597072&partnerID=8YFLogxK

UR - http://www.scopus.com/inward/citedby.url?scp=85043597072&partnerID=8YFLogxK

U2 - 10.3233/JAD-170365

DO - 10.3233/JAD-170365

M3 - Article

C2 - 29480171

AN - SCOPUS:85043597072

VL - 62

SP - 699

EP - 711

JO - Journal of Alzheimer's Disease

JF - Journal of Alzheimer's Disease

SN - 1387-2877

IS - 2

ER -