Exercise: A "new drug" for elderly patients with chronic heart failure

Roberto Antonicelli, Liana Spazzafumo, Simonetta Scalvini, Fabiola Olivieri, Maria Vittoria Matassini, Gianfranco Parati, Donatella Del Sindaco, Raffaella Gallo, Fabrizia Lattanzio

Research output: Contribution to journalArticlepeer-review


Patients with chronic heart failure (CHF) experience progressive deterioration of functional capacity and quality of life (QoL). This prospective, randomized, controlled trial assesses the effect of exercise training (ET) protocol on functional capacity, rehospitalization, and QoL in CHF patients older than 70 years compared with a control group. A total of 343 elderly patients with stable CHF (age, 76.90±5.67, men, 195, 56.9%) were randomized to ET (TCG, n=170) or usual care (UCG, n=173). The ET protocol involved supervised training sessions for 3 months in the hospital followed by home-telemonitored sessions for 3 months. Assessments, performed at baseline and at 3 and 6 months, included: ECG, resting echocardiography, NTproBNP, 6-minute walk test (6MWT), Minnesota Living with Heart Failure Questionnaire, and comprehensive geriatric assessment with the InterRAI-HC instrument. As compared to UCG, ET patients at 6 months showed: i) significantly increased 6MWT distance (450±83 vs. 290±97 m, p

Original languageEnglish
Pages (from-to)860-872
Number of pages13
Issue number5
Publication statusPublished - 2016


  • 6MWT
  • Chronic heart failure
  • Elderly CHF patients
  • Physical exercise
  • QoL
  • Quality of life

ASJC Scopus subject areas

  • Ageing
  • Cell Biology


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