Exercise and distribution of inspired gas in patients with obstructive pulmonary disease

A. Cutillo, A. H. Bigler, R. Perondi, M. Turiel, S. Watanabe, A. D. Renzetti

Research output: Contribution to journalArticle

Abstract

The effects of moderate exercise on the distribution of inspired gas and efficiency of ventilation were studied by the multibreath nitrogen washout method in three subjects with asymptomatic asthma and 11 patients with chronic obstructive pulmonary disease (COPD). The nitrogen washout curves were analyzed according to a lung model consisting of a poorly ventilated compartment (slow space) and one or more better ventilated compartments (intermediate and fast compartments). The overall efficiency of ventilation was also estimated by the lung clearance index (LCI). An increase in the ventilation of both well ventilated and poorly ventilated lung compartments was generally observed during exercise; however, the magnitude of the change in the ventilation of the slow compartment in response to exercise varied from subject to subject; the change was related to the degree of functional impairment, as expressed by current pulmonary function tests (spirometry, airway resistance, and arterial blood gas measurements). The magnitude of the change in the ventilation of the better ventilated lung compartments did not vary significantly with the degree of functional impairment. LCI showed no uniform changes with exercise. Our results indicate that in patients with obstructive lung disease the effect of exercise on the distribution of inspired gas tends to vary with the severity of the disease. The nitrogen washout data also suggest that in these patients the pattern of gas distribution during exercise is not compatible with a high level of ventilatory efficiency.

Original languageEnglish
Pages (from-to)891-901
Number of pages11
JournalClinical Respiratory Physiology
Volume17
Issue number6
Publication statusPublished - 1981

Fingerprint

Obstructive Lung Diseases
Gases
Ventilation
Exercise
Lung
Nitrogen
Airway Resistance
Spirometry
Respiratory Function Tests
Chronic Obstructive Pulmonary Disease
Asthma

ASJC Scopus subject areas

  • Pulmonary and Respiratory Medicine

Cite this

Cutillo, A., Bigler, A. H., Perondi, R., Turiel, M., Watanabe, S., & Renzetti, A. D. (1981). Exercise and distribution of inspired gas in patients with obstructive pulmonary disease. Clinical Respiratory Physiology, 17(6), 891-901.

Exercise and distribution of inspired gas in patients with obstructive pulmonary disease. / Cutillo, A.; Bigler, A. H.; Perondi, R.; Turiel, M.; Watanabe, S.; Renzetti, A. D.

In: Clinical Respiratory Physiology, Vol. 17, No. 6, 1981, p. 891-901.

Research output: Contribution to journalArticle

Cutillo, A, Bigler, AH, Perondi, R, Turiel, M, Watanabe, S & Renzetti, AD 1981, 'Exercise and distribution of inspired gas in patients with obstructive pulmonary disease', Clinical Respiratory Physiology, vol. 17, no. 6, pp. 891-901.
Cutillo, A. ; Bigler, A. H. ; Perondi, R. ; Turiel, M. ; Watanabe, S. ; Renzetti, A. D. / Exercise and distribution of inspired gas in patients with obstructive pulmonary disease. In: Clinical Respiratory Physiology. 1981 ; Vol. 17, No. 6. pp. 891-901.
@article{a9fe30b2d1da4e19acc95fc5f1a7bcae,
title = "Exercise and distribution of inspired gas in patients with obstructive pulmonary disease",
abstract = "The effects of moderate exercise on the distribution of inspired gas and efficiency of ventilation were studied by the multibreath nitrogen washout method in three subjects with asymptomatic asthma and 11 patients with chronic obstructive pulmonary disease (COPD). The nitrogen washout curves were analyzed according to a lung model consisting of a poorly ventilated compartment (slow space) and one or more better ventilated compartments (intermediate and fast compartments). The overall efficiency of ventilation was also estimated by the lung clearance index (LCI). An increase in the ventilation of both well ventilated and poorly ventilated lung compartments was generally observed during exercise; however, the magnitude of the change in the ventilation of the slow compartment in response to exercise varied from subject to subject; the change was related to the degree of functional impairment, as expressed by current pulmonary function tests (spirometry, airway resistance, and arterial blood gas measurements). The magnitude of the change in the ventilation of the better ventilated lung compartments did not vary significantly with the degree of functional impairment. LCI showed no uniform changes with exercise. Our results indicate that in patients with obstructive lung disease the effect of exercise on the distribution of inspired gas tends to vary with the severity of the disease. The nitrogen washout data also suggest that in these patients the pattern of gas distribution during exercise is not compatible with a high level of ventilatory efficiency.",
author = "A. Cutillo and Bigler, {A. H.} and R. Perondi and M. Turiel and S. Watanabe and Renzetti, {A. D.}",
year = "1981",
language = "English",
volume = "17",
pages = "891--901",
journal = "Clinical Respiratory Physiology",
issn = "0272-7587",
publisher = "Pergamon Press Ltd.",
number = "6",

}

TY - JOUR

T1 - Exercise and distribution of inspired gas in patients with obstructive pulmonary disease

AU - Cutillo, A.

AU - Bigler, A. H.

AU - Perondi, R.

AU - Turiel, M.

AU - Watanabe, S.

AU - Renzetti, A. D.

PY - 1981

Y1 - 1981

N2 - The effects of moderate exercise on the distribution of inspired gas and efficiency of ventilation were studied by the multibreath nitrogen washout method in three subjects with asymptomatic asthma and 11 patients with chronic obstructive pulmonary disease (COPD). The nitrogen washout curves were analyzed according to a lung model consisting of a poorly ventilated compartment (slow space) and one or more better ventilated compartments (intermediate and fast compartments). The overall efficiency of ventilation was also estimated by the lung clearance index (LCI). An increase in the ventilation of both well ventilated and poorly ventilated lung compartments was generally observed during exercise; however, the magnitude of the change in the ventilation of the slow compartment in response to exercise varied from subject to subject; the change was related to the degree of functional impairment, as expressed by current pulmonary function tests (spirometry, airway resistance, and arterial blood gas measurements). The magnitude of the change in the ventilation of the better ventilated lung compartments did not vary significantly with the degree of functional impairment. LCI showed no uniform changes with exercise. Our results indicate that in patients with obstructive lung disease the effect of exercise on the distribution of inspired gas tends to vary with the severity of the disease. The nitrogen washout data also suggest that in these patients the pattern of gas distribution during exercise is not compatible with a high level of ventilatory efficiency.

AB - The effects of moderate exercise on the distribution of inspired gas and efficiency of ventilation were studied by the multibreath nitrogen washout method in three subjects with asymptomatic asthma and 11 patients with chronic obstructive pulmonary disease (COPD). The nitrogen washout curves were analyzed according to a lung model consisting of a poorly ventilated compartment (slow space) and one or more better ventilated compartments (intermediate and fast compartments). The overall efficiency of ventilation was also estimated by the lung clearance index (LCI). An increase in the ventilation of both well ventilated and poorly ventilated lung compartments was generally observed during exercise; however, the magnitude of the change in the ventilation of the slow compartment in response to exercise varied from subject to subject; the change was related to the degree of functional impairment, as expressed by current pulmonary function tests (spirometry, airway resistance, and arterial blood gas measurements). The magnitude of the change in the ventilation of the better ventilated lung compartments did not vary significantly with the degree of functional impairment. LCI showed no uniform changes with exercise. Our results indicate that in patients with obstructive lung disease the effect of exercise on the distribution of inspired gas tends to vary with the severity of the disease. The nitrogen washout data also suggest that in these patients the pattern of gas distribution during exercise is not compatible with a high level of ventilatory efficiency.

UR - http://www.scopus.com/inward/record.url?scp=0019759861&partnerID=8YFLogxK

UR - http://www.scopus.com/inward/citedby.url?scp=0019759861&partnerID=8YFLogxK

M3 - Article

C2 - 7317665

AN - SCOPUS:0019759861

VL - 17

SP - 891

EP - 901

JO - Clinical Respiratory Physiology

JF - Clinical Respiratory Physiology

SN - 0272-7587

IS - 6

ER -