TY - JOUR
T1 - Exercise attenuates the clinical, synaptic and dendritic abnormalities of experimental autoimmune encephalomyelitis
AU - Rossi, Silvia
AU - Furlan, Roberto
AU - De Chiara, Valentina
AU - Musella, Alessandra
AU - Lo Giudice, Temistocle
AU - Mataluni, Giorgia
AU - Cavasinni, Francesca
AU - Cantarella, Cristina
AU - Bernardi, Giorgio
AU - Muzio, Luca
AU - Martorana, Alessandro
AU - Martino, Gianvito
AU - Centonze, Diego
PY - 2009/10
Y1 - 2009/10
N2 - Voluntary exercise is beneficial in models of primarily neurodegenerative disorders. Whether exercise also affects inflammatory neurodegeneration is unknown. In the present study, we evaluated the clinical, synaptic and neuropathological effects of voluntary wheel running in mice with myelin oligodendrocyte glycoprotein (MOG)-induced experimental autoimmune encephalomyelitis (EAE), a model of multiple sclerosis. Exercising EAE mice exhibited less severe neurological deficits compared to control EAE animals. The sensitivity of striatal GABA synapses to the stimulation of cannabinoid CB1 receptors was dramatically downregulated following EAE induction, and was rescued by exercise in EAE mice with access to a running wheel. Finally, we found that exercise was able to contrast dendritic spine loss induced by EAE in striatal neurons, although the degree of inflammatory response was similar in the two experimental groups. Our work suggests that life style and experiences can impact the clinical course of inflammatory neurodegenerative diseases by affecting their synaptic bases.
AB - Voluntary exercise is beneficial in models of primarily neurodegenerative disorders. Whether exercise also affects inflammatory neurodegeneration is unknown. In the present study, we evaluated the clinical, synaptic and neuropathological effects of voluntary wheel running in mice with myelin oligodendrocyte glycoprotein (MOG)-induced experimental autoimmune encephalomyelitis (EAE), a model of multiple sclerosis. Exercising EAE mice exhibited less severe neurological deficits compared to control EAE animals. The sensitivity of striatal GABA synapses to the stimulation of cannabinoid CB1 receptors was dramatically downregulated following EAE induction, and was rescued by exercise in EAE mice with access to a running wheel. Finally, we found that exercise was able to contrast dendritic spine loss induced by EAE in striatal neurons, although the degree of inflammatory response was similar in the two experimental groups. Our work suggests that life style and experiences can impact the clinical course of inflammatory neurodegenerative diseases by affecting their synaptic bases.
KW - Cannabinoid CB1 receptors
KW - Dendritic spines
KW - EAE
KW - IPSC
KW - Multiple sclerosis
KW - Neuroprotection
KW - Running wheel
KW - Striatum
UR - http://www.scopus.com/inward/record.url?scp=69749099133&partnerID=8YFLogxK
UR - http://www.scopus.com/inward/citedby.url?scp=69749099133&partnerID=8YFLogxK
U2 - 10.1016/j.nbd.2009.06.013
DO - 10.1016/j.nbd.2009.06.013
M3 - Article
C2 - 19591937
AN - SCOPUS:69749099133
VL - 36
SP - 51
EP - 59
JO - Neurobiology of Disease
JF - Neurobiology of Disease
SN - 0969-9961
IS - 1
ER -