Exercise hyperpnea in chronic heart failure: Relationships to lung stiffness and expiratory flow limitation

Piergiuseppe Agostoni, Riccardo Pellegrino, Cristina Conca, Joseph R. Rodarte, Vito Brusasco

Research output: Contribution to journalArticle

Abstract

The changes in breathing pattern and lung mechanics in response to incremental exercise were compared in 14 subjects with chronic heart failure and 15 normal subjects. In chronic heart failure subjects, exercise hyperpnea was achieved by increasing breathing frequency more than tidal volume. The rate of increase in breathing frequency with carbon dioxide output was inversely correlated (r = -0.61, P <0.05) with dynamic lung compliance measured at rest, but not with static lung compliance either at rest or at maximum exercise. Although decrease in expiratory flow reserve near functional residual capacity in chronic heart failure occurred earlier with exercise than in the normal subjects (P <0.01), it was not correlated with changes in breathing pattern or occurrence of tachypnea. Tachypnea was achieved in chronic heart failure subjects with an increase in duty cycle because of a greater than normal decrease in expiratory time with exercise. We conclude that in chronic heart failure preexisting increase in lung stiffness plays a significant role in causing tachypnea during exercise. The results of the present study do not support the hypothesis that dynamic compression of the airways downstream from the flow-limiting segment occurring during exercise contributes to hyperpnea.

Original languageEnglish
Pages (from-to)1409-1416
Number of pages8
JournalJournal of Applied Physiology
Volume92
Issue number4
Publication statusPublished - 2002

Keywords

  • Breathing pattern
  • Expiratory flow reserve
  • Flow-volume curves
  • Static and dynamic lung compliance

ASJC Scopus subject areas

  • Physiology
  • Endocrinology
  • Orthopedics and Sports Medicine
  • Physical Therapy, Sports Therapy and Rehabilitation

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