Abstract
Previous studies have suggested the benefits of physical exercise for patients on dialysis. We conducted the Exercise Introduction to Enhance Performance in Dialysis trial, a 6-month randomized, multicenter trial to test whether a simple, personalized walking exercise program at home, managed by dialysis staff, improves functional status in adult patients on dialysis. The main study outcomes included change in physical performance at 6 months, assessed by the 6-minute walking test and the five times sit-to-stand test, and in quality of life, assessed by the Kidney Disease Quality of Life Short Form (KDQOL-SF) questionnaire. We randomized 296 patients to normal physical activity (control; n=145) or walking exercise (n=151); 227 patients (exercise n=104; control n=123) repeated the 6-month evaluations. The distance covered during the 6-minute walking test improved in the exercise group (mean distance6SD: baseline, 328696 m; 6 months, 3676113 m) but not in the control group (baseline, 3216107 m; 6 months, 3246116 m; P,0.001 between groups). Similarly, the five times sit-to-stand test time improved in the exercise group (mean time6SD: baseline, 20.566.0 seconds; 6 months, 18.265.7 seconds) but not in the control group (baseline, 20.965.8 seconds; 6 months, 20.266.4 seconds; P=0.001 between groups). The cognitive function score (P=0.04) and quality of social interaction score (P=0.01) in the kidney disease component of the KDQOL-SF improved significantly in the exercise arm compared with the control arm. Hence, a simple, personalized, home-based, low-intensity exercise program managed by dialysis staff may improve physical performance and quality of life in patients on dialysis. Copyright © 2017 by the American Society of Nephrology well documented,5 how exercise training should be articulated
Original language | English |
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Pages (from-to) | 1259-1268 |
Number of pages | 10 |
Journal | Journal of the American Society of Nephrology |
Volume | 28 |
Issue number | 4 |
DOIs | |
Publication status | Published - 2017 |
Keywords
- albumin
- calcium
- cholesterol
- creatinine
- glucose
- parathyroid hormone
- phosphate
- triacylglycerol
- urea
- adult
- arm exercise
- Article
- clinical assessment
- cognition
- comparative study
- continuous ambulatory peritoneal dialysis
- controlled study
- exercise
- exercise test
- female
- functional status
- hemodialysis
- home care
- human
- kidney disease
- Kidney Disease Quality of Life Short Form questionnaire
- major clinical study
- male
- managed care
- multicenter study
- outcome assessment
- personalized walking exercise program
- physical activity
- physical capacity
- physical performance
- priority journal
- quality of life
- questionnaire
- randomized controlled trial
- sit to stand test
- six minute walk test
- social interaction
- time to treatment
- urinary tract disease assessment
- walking
- clinical trial
- fitness
- kinesiotherapy
- middle aged
- multimodality cancer therapy
- Renal Insufficiency, Chronic
- Combined Modality Therapy
- Exercise Therapy
- Female
- Humans
- Male
- Middle Aged
- Physical Fitness
- Quality of Life
- Renal Dialysis
- Walking