Exercise-induced changes in exhaled nitric oxide in heart failure

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Background: In heart failure abnormalities of pulmonary function are frequently observed as shown by hyperpnea, reduced lung compliance, reduced alveolar-capillary gas diffusion, positive methacholine challenge and, during exercise, early expiratory flow limitation. Nitric oxide (NO) might be related to all the above abnormalities. Aims: We evaluated whether a correlation between exhaled NO (eNO) and lung function exists at rest and during exercise in heart failure. Methods: We studied 33 chronic heart failure patients and 11 healthy subjects with: (a) standard pulmonary function, (b) lung diffusion for carbon monoxide (DLCO) including its subcomponents, capillary volume and membrane resistance and eNO both at rest and during light exercise, (c) maximal cycloergometer cardiopulmonary exercise test. Results: Forced expiratory volume in 1 s (FEV1) was reduced in heart failure patients (83±17% of predicted), as was DLCO (75±18% of predicted) due to reduced membrane resistance (32.6±10.3 ml mmHg-1 min-1 vs. 39.9±6.9 in patients vs. controls, P2 might be due to hemoglobin oxygenation, which binds NO to hemoglobin.

Original languageEnglish
Pages (from-to)551-554
Number of pages4
JournalEuropean Journal of Heart Failure
Issue number5
Publication statusPublished - Aug 2004


  • Exercise
  • Heart failure
  • Lung diffusion
  • Nitric oxide

ASJC Scopus subject areas

  • Cardiology and Cardiovascular Medicine


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