TY - JOUR
T1 - Exercise-Induced Pulmonary Edema in Heart Failure
AU - Agostoni, Piergiuseppe
AU - Cattadori, Gaia
AU - Bianchi, Michele
AU - Wasserman, Karlman
PY - 2003/11/25
Y1 - 2003/11/25
N2 - Background-In heart failure (HF) patients, exercise may increase pulmonary capillary hydrostatic pressure and thereby generate pulmonary edema. If pulmonary edema developed, alveolar-capillary membrane conductance (DM), measured immediately after exercise, would decrease. To test this hypothesis, we measured DM before and at 2 and 60 minutes after exercise. Methods and Results-We studied 10 HF patients with exercise-induced periodic breathing, 10 with peak V̇O2 ≤15 mL · min-1 · kg-1 (severe HF), 10 with V̇O2=15 to 20 mL · min-1 · kg-1 (moderate HF), and 10 normal subjects (control). Using the Roughton-Forster technique, we measured carbon monoxide diffusion capacity (DLCO) and its components, capillary blood volume (VC) and DM, at rest and 2 and 60 minutes after exercise. At rest, DLCO and DM were lowest in periodic breathing and highest in control subjects. DM decreased in periodic breathing, severe HF, and moderate HF (-7.83±3.98, -5.57±2.03, and -3.85±3.53 mL · min-1 · mm Hg-1, respectively; P
AB - Background-In heart failure (HF) patients, exercise may increase pulmonary capillary hydrostatic pressure and thereby generate pulmonary edema. If pulmonary edema developed, alveolar-capillary membrane conductance (DM), measured immediately after exercise, would decrease. To test this hypothesis, we measured DM before and at 2 and 60 minutes after exercise. Methods and Results-We studied 10 HF patients with exercise-induced periodic breathing, 10 with peak V̇O2 ≤15 mL · min-1 · kg-1 (severe HF), 10 with V̇O2=15 to 20 mL · min-1 · kg-1 (moderate HF), and 10 normal subjects (control). Using the Roughton-Forster technique, we measured carbon monoxide diffusion capacity (DLCO) and its components, capillary blood volume (VC) and DM, at rest and 2 and 60 minutes after exercise. At rest, DLCO and DM were lowest in periodic breathing and highest in control subjects. DM decreased in periodic breathing, severe HF, and moderate HF (-7.83±3.98, -5.57±2.03, and -3.85±3.53 mL · min-1 · mm Hg-1, respectively; P
KW - Edema
KW - Exercise
KW - Heart failure
KW - Lung
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U2 - 10.1161/01.CIR.0000097115.61309.59
DO - 10.1161/01.CIR.0000097115.61309.59
M3 - Article
C2 - 14581402
AN - SCOPUS:0344844417
VL - 108
SP - 2666
EP - 2671
JO - Circulation
JF - Circulation
SN - 0009-7322
IS - 21
ER -