Exercise-Induced Pulmonary Edema in Heart Failure

Background-In heart failure (HF) patients, exercise may increase pulmonary capillary hydrostatic pressure and thereby generate pulmonary edema. If pulmonary edema developed, alveolar-capillary membrane conductance (DM), measured immediately after exercise, would decrease. To test this hypothesis, we measured DM before and at 2 and 60 minutes after exercise. Methods and Results-We studied 10 HF patients with exercise-induced periodic breathing, 10 with peak V̇O₂ ≤15 mL · min^-1 · kg^-1 (severe HF), 10 with V̇O₂=15 to 20 mL · min^-1 · kg^-1 (moderate HF), and 10 normal subjects (control). Using the Roughton-Forster technique, we measured carbon monoxide diffusion capacity (DLCO) and its components, capillary blood volume (VC) and DM, at rest and 2 and 60 minutes after exercise. At rest, DLCO and DM were lowest in periodic breathing and highest in control subjects. DM decreased in periodic breathing, severe HF, and moderate HF (-7.83±3.98, -5.57±2.03, and -3.85±3.53 mL · min^-1 · mm Hg^-1, respectively; P