Exercise-induced T-wave normalization predicts recovery of regional contractile function after anterior myocardial infarction

Giuseppe Pizzetti, M. Montorfano, G. Belotti, A. Margonato, C. Ballarotto, S. L. Chierchia

Research output: Contribution to journalArticlepeer-review


Aims. We investigated the ability of T-wave pseudonormalization and ST-segment elevation, which are demonstrated in infarct-related leads during submaximal exercise testing, to predict late recovery of contractile function. Methods. We studied 88 consecutive patients (73 males, mean age 59 ± 8 years) with anterior infarction, persistent T-wave inversion and a documented lesion of the proximal segment of the left anterior descending coronary artery. They all underwent 2D-echocardiography on admission, 4 weeks as well as 6 months after myocardial infarction to evaluate the dysfunction score and the ejection fraction. Submaximal (75% of maximal predicted heart rate) exercise testing was performed in 80 patients 2 weeks after myocardial infarction following discontinuation of treatment. Results. During exercise testing, 59 of the 88 patients showing negative T-waves on the resting electrocardiogram exhibited pseudonormalization (group A) in at least three adjacent precordial leads, whilst 29 (group B) did not. Patients of group A more frequently exhibited an early creatine kinase peak (41% vs 24%, P <0.05) and residual angiographic perfusion (97% vs 69%, P <0.05). The dysfunction score did not change in group B (from 19 ± 7 to 22 ± 4), but decreased in group A (from 18 ± 4 to 11 ± 6, P <0.05). The ejection fraction was similar in the two groups on admission (group A: 48 ± 7%, group B: 45 ± 10%), but was significantly different at 4-week (52 ± 99 vs 42 ± 11%, P <0.05) and 6-month follow-up (58 ± 9 vs 44 ± 10%, P <0.01). The concomitant presence of ST-segment elevation and T-wave normalization showed the highest positive predictive value for left ventricular function recovery (100%). Conclusions. T-wave normalization induced by submaximal exercise test is frequently associated with residual perfusion to the infarct area and predicts progressive improvement in regional wall motion, especially if associated with ST-segment elevation. Therefore, these electrocardiographic findings may be used as easily obtainable markers of residual viability that predict late recovery in contractile function.

Original languageEnglish
Pages (from-to)420-428
Number of pages9
JournalEuropean Heart Journal
Issue number3
Publication statusPublished - Mar 1998


  • Recent anterior myocardial infarction
  • T-wave pseudonormalization
  • Viability

ASJC Scopus subject areas

  • Cardiology and Cardiovascular Medicine


Dive into the research topics of 'Exercise-induced T-wave normalization predicts recovery of regional contractile function after anterior myocardial infarction'. Together they form a unique fingerprint.

Cite this