Abstract
Mechanisms underlying the exercise-induced increase in tissue plasminogen activator (t-PA) levels are still controversial and the role played by adrenergic activation and metabolic acidosis in endothelial t-PA secretion is under discussion. Fibrinolytic parameters and catecholamines were investigated in 20 untrained healthy males who performed a well-standardised treadmill stress test with the continuous measurement of cardiorespiratory and metabolic parameters for the exact determination of anaerobic threshold (AT). Components of the fibrinolytic system showed only slight modifications during the aerobic phase of the exercise in spite of a marked increase in adrenaline levels (+127%). Only after the reaching AT euglobulin lysis time, did t-PA (activity and antigen) and plasminogen activator inhibitor (PAI-1) (activity and antigen) become clearly different from baseline and t-PA increase was more marked than adrenaline rise. Thirty minutes after the end of exercise t-PA levels were still higher than baseline, whereas adrenaline levels quickly normalised. Thus, the exercise-induced secretion of t-PA seems to be related not only to adrenergic activation per se but also to metabolic acidosis, which is at least in part adrenaline-induced.
| Original language | English |
|---|---|
| Pages (from-to) | 363-367 |
| Number of pages | 5 |
| Journal | Fibrinolysis and Proteolysis |
| Volume | 9 |
| Issue number | 6 |
| DOIs | |
| Publication status | Published - 1995 |
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ASJC Scopus subject areas
- Hematology
Cite this
Exercise-induced tissue plasminogen activator increase : a role for metabolic acidosis. / Boddi, M.; Paniccia, R.; Coppo, M.; Bandinelli, B.; Francalanci, I.; Prisco, D.; Abbate, R.; Gensini, G. F.
In: Fibrinolysis and Proteolysis, Vol. 9, No. 6, 1995, p. 363-367.Research output: Contribution to journal › Article
}
TY - JOUR
T1 - Exercise-induced tissue plasminogen activator increase
T2 - a role for metabolic acidosis
AU - Boddi, M.
AU - Paniccia, R.
AU - Coppo, M.
AU - Bandinelli, B.
AU - Francalanci, I.
AU - Prisco, D.
AU - Abbate, R.
AU - Gensini, G. F.
PY - 1995
Y1 - 1995
N2 - Mechanisms underlying the exercise-induced increase in tissue plasminogen activator (t-PA) levels are still controversial and the role played by adrenergic activation and metabolic acidosis in endothelial t-PA secretion is under discussion. Fibrinolytic parameters and catecholamines were investigated in 20 untrained healthy males who performed a well-standardised treadmill stress test with the continuous measurement of cardiorespiratory and metabolic parameters for the exact determination of anaerobic threshold (AT). Components of the fibrinolytic system showed only slight modifications during the aerobic phase of the exercise in spite of a marked increase in adrenaline levels (+127%). Only after the reaching AT euglobulin lysis time, did t-PA (activity and antigen) and plasminogen activator inhibitor (PAI-1) (activity and antigen) become clearly different from baseline and t-PA increase was more marked than adrenaline rise. Thirty minutes after the end of exercise t-PA levels were still higher than baseline, whereas adrenaline levels quickly normalised. Thus, the exercise-induced secretion of t-PA seems to be related not only to adrenergic activation per se but also to metabolic acidosis, which is at least in part adrenaline-induced.
AB - Mechanisms underlying the exercise-induced increase in tissue plasminogen activator (t-PA) levels are still controversial and the role played by adrenergic activation and metabolic acidosis in endothelial t-PA secretion is under discussion. Fibrinolytic parameters and catecholamines were investigated in 20 untrained healthy males who performed a well-standardised treadmill stress test with the continuous measurement of cardiorespiratory and metabolic parameters for the exact determination of anaerobic threshold (AT). Components of the fibrinolytic system showed only slight modifications during the aerobic phase of the exercise in spite of a marked increase in adrenaline levels (+127%). Only after the reaching AT euglobulin lysis time, did t-PA (activity and antigen) and plasminogen activator inhibitor (PAI-1) (activity and antigen) become clearly different from baseline and t-PA increase was more marked than adrenaline rise. Thirty minutes after the end of exercise t-PA levels were still higher than baseline, whereas adrenaline levels quickly normalised. Thus, the exercise-induced secretion of t-PA seems to be related not only to adrenergic activation per se but also to metabolic acidosis, which is at least in part adrenaline-induced.
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UR - http://www.scopus.com/inward/citedby.url?scp=0029610744&partnerID=8YFLogxK
U2 - 10.1016/S0268-9499(95)80084-0
DO - 10.1016/S0268-9499(95)80084-0
M3 - Article
VL - 9
SP - 363
EP - 367
JO - Fibrinolysis and Proteolysis
JF - Fibrinolysis and Proteolysis
SN - 1369-0191
IS - 6
ER -