Exercise-induced tissue plasminogen activator increase

a role for metabolic acidosis

M. Boddi, R. Paniccia, M. Coppo, B. Bandinelli, I. Francalanci, D. Prisco, R. Abbate, G. F. Gensini

Research output: Contribution to journalArticle

Abstract

Mechanisms underlying the exercise-induced increase in tissue plasminogen activator (t-PA) levels are still controversial and the role played by adrenergic activation and metabolic acidosis in endothelial t-PA secretion is under discussion. Fibrinolytic parameters and catecholamines were investigated in 20 untrained healthy males who performed a well-standardised treadmill stress test with the continuous measurement of cardiorespiratory and metabolic parameters for the exact determination of anaerobic threshold (AT). Components of the fibrinolytic system showed only slight modifications during the aerobic phase of the exercise in spite of a marked increase in adrenaline levels (+127%). Only after the reaching AT euglobulin lysis time, did t-PA (activity and antigen) and plasminogen activator inhibitor (PAI-1) (activity and antigen) become clearly different from baseline and t-PA increase was more marked than adrenaline rise. Thirty minutes after the end of exercise t-PA levels were still higher than baseline, whereas adrenaline levels quickly normalised. Thus, the exercise-induced secretion of t-PA seems to be related not only to adrenergic activation per se but also to metabolic acidosis, which is at least in part adrenaline-induced.

Original languageEnglish
Pages (from-to)363-367
Number of pages5
JournalFibrinolysis and Proteolysis
Volume9
Issue number6
DOIs
Publication statusPublished - 1995

Fingerprint

Tissue Plasminogen Activator
Acidosis
Epinephrine
Anaerobic Threshold
Plasminogen Activator Inhibitor 1
Exercise Test
Adrenergic Agents
Fibrin Clot Lysis Time
Antigens
Endothelium
Catecholamines
Exercise

ASJC Scopus subject areas

  • Hematology

Cite this

Boddi, M., Paniccia, R., Coppo, M., Bandinelli, B., Francalanci, I., Prisco, D., ... Gensini, G. F. (1995). Exercise-induced tissue plasminogen activator increase: a role for metabolic acidosis. Fibrinolysis and Proteolysis, 9(6), 363-367. https://doi.org/10.1016/S0268-9499(95)80084-0

Exercise-induced tissue plasminogen activator increase : a role for metabolic acidosis. / Boddi, M.; Paniccia, R.; Coppo, M.; Bandinelli, B.; Francalanci, I.; Prisco, D.; Abbate, R.; Gensini, G. F.

In: Fibrinolysis and Proteolysis, Vol. 9, No. 6, 1995, p. 363-367.

Research output: Contribution to journalArticle

Boddi, M, Paniccia, R, Coppo, M, Bandinelli, B, Francalanci, I, Prisco, D, Abbate, R & Gensini, GF 1995, 'Exercise-induced tissue plasminogen activator increase: a role for metabolic acidosis', Fibrinolysis and Proteolysis, vol. 9, no. 6, pp. 363-367. https://doi.org/10.1016/S0268-9499(95)80084-0
Boddi, M. ; Paniccia, R. ; Coppo, M. ; Bandinelli, B. ; Francalanci, I. ; Prisco, D. ; Abbate, R. ; Gensini, G. F. / Exercise-induced tissue plasminogen activator increase : a role for metabolic acidosis. In: Fibrinolysis and Proteolysis. 1995 ; Vol. 9, No. 6. pp. 363-367.
@article{4fc96aa40bbe4e728233682d4309d966,
title = "Exercise-induced tissue plasminogen activator increase: a role for metabolic acidosis",
abstract = "Mechanisms underlying the exercise-induced increase in tissue plasminogen activator (t-PA) levels are still controversial and the role played by adrenergic activation and metabolic acidosis in endothelial t-PA secretion is under discussion. Fibrinolytic parameters and catecholamines were investigated in 20 untrained healthy males who performed a well-standardised treadmill stress test with the continuous measurement of cardiorespiratory and metabolic parameters for the exact determination of anaerobic threshold (AT). Components of the fibrinolytic system showed only slight modifications during the aerobic phase of the exercise in spite of a marked increase in adrenaline levels (+127{\%}). Only after the reaching AT euglobulin lysis time, did t-PA (activity and antigen) and plasminogen activator inhibitor (PAI-1) (activity and antigen) become clearly different from baseline and t-PA increase was more marked than adrenaline rise. Thirty minutes after the end of exercise t-PA levels were still higher than baseline, whereas adrenaline levels quickly normalised. Thus, the exercise-induced secretion of t-PA seems to be related not only to adrenergic activation per se but also to metabolic acidosis, which is at least in part adrenaline-induced.",
author = "M. Boddi and R. Paniccia and M. Coppo and B. Bandinelli and I. Francalanci and D. Prisco and R. Abbate and Gensini, {G. F.}",
year = "1995",
doi = "10.1016/S0268-9499(95)80084-0",
language = "English",
volume = "9",
pages = "363--367",
journal = "Fibrinolysis and Proteolysis",
issn = "1369-0191",
publisher = "Churchill Livingstone",
number = "6",

}

TY - JOUR

T1 - Exercise-induced tissue plasminogen activator increase

T2 - a role for metabolic acidosis

AU - Boddi, M.

AU - Paniccia, R.

AU - Coppo, M.

AU - Bandinelli, B.

AU - Francalanci, I.

AU - Prisco, D.

AU - Abbate, R.

AU - Gensini, G. F.

PY - 1995

Y1 - 1995

N2 - Mechanisms underlying the exercise-induced increase in tissue plasminogen activator (t-PA) levels are still controversial and the role played by adrenergic activation and metabolic acidosis in endothelial t-PA secretion is under discussion. Fibrinolytic parameters and catecholamines were investigated in 20 untrained healthy males who performed a well-standardised treadmill stress test with the continuous measurement of cardiorespiratory and metabolic parameters for the exact determination of anaerobic threshold (AT). Components of the fibrinolytic system showed only slight modifications during the aerobic phase of the exercise in spite of a marked increase in adrenaline levels (+127%). Only after the reaching AT euglobulin lysis time, did t-PA (activity and antigen) and plasminogen activator inhibitor (PAI-1) (activity and antigen) become clearly different from baseline and t-PA increase was more marked than adrenaline rise. Thirty minutes after the end of exercise t-PA levels were still higher than baseline, whereas adrenaline levels quickly normalised. Thus, the exercise-induced secretion of t-PA seems to be related not only to adrenergic activation per se but also to metabolic acidosis, which is at least in part adrenaline-induced.

AB - Mechanisms underlying the exercise-induced increase in tissue plasminogen activator (t-PA) levels are still controversial and the role played by adrenergic activation and metabolic acidosis in endothelial t-PA secretion is under discussion. Fibrinolytic parameters and catecholamines were investigated in 20 untrained healthy males who performed a well-standardised treadmill stress test with the continuous measurement of cardiorespiratory and metabolic parameters for the exact determination of anaerobic threshold (AT). Components of the fibrinolytic system showed only slight modifications during the aerobic phase of the exercise in spite of a marked increase in adrenaline levels (+127%). Only after the reaching AT euglobulin lysis time, did t-PA (activity and antigen) and plasminogen activator inhibitor (PAI-1) (activity and antigen) become clearly different from baseline and t-PA increase was more marked than adrenaline rise. Thirty minutes after the end of exercise t-PA levels were still higher than baseline, whereas adrenaline levels quickly normalised. Thus, the exercise-induced secretion of t-PA seems to be related not only to adrenergic activation per se but also to metabolic acidosis, which is at least in part adrenaline-induced.

UR - http://www.scopus.com/inward/record.url?scp=0029610744&partnerID=8YFLogxK

UR - http://www.scopus.com/inward/citedby.url?scp=0029610744&partnerID=8YFLogxK

U2 - 10.1016/S0268-9499(95)80084-0

DO - 10.1016/S0268-9499(95)80084-0

M3 - Article

VL - 9

SP - 363

EP - 367

JO - Fibrinolysis and Proteolysis

JF - Fibrinolysis and Proteolysis

SN - 1369-0191

IS - 6

ER -