Exercise intolerance in chronic heart failure: Mechanisms and therapies. Part i

Massimo F. Piepoli, Marco Guazzi, Giuseppe Boriani, Mariantonietta Cicoira, Ugo Corrà, Luciano Dalla Libera, Michele Emdin, Donato Mele, Claudio Passino, Giorgio Vescovo, Carlo Vigorito, Giovanni Q. Villani, Piergiuseppe Agostoni

Research output: Contribution to journalArticle

Abstract

Muscular fatigue and dyspnoea on exertion are among the most common symptoms in chronic heart failure; however their origin is still poorly understood. Several studies have shown that cardiac dysfunction alone cannot fully explain their origin, but the contribution of the multiorgan failure present in this syndrome must be highlighted. In this study, divided in two parts (see part II: pp. 643-648), we aimed to summarize the existing evidence and the most controversial aspects of the complex interplay of different factors involved in symptom generation. In this first part of the review, six key factors are revised: the heart, the lung, the skeletal muscle, the hormonal changes, the O2 delivery to the periphery, the endothelium. In the second part, the role of the excitatory reflexes and the cardiac cachexia will be presented, and finally, the potential therapeutic implications are discussed. We believe that a better knowledge of the pathophysiology of this syndrome may contribute to the management of the patients and to the improvement in their stress tolerance and quality of life.

Original languageEnglish
Pages (from-to)637-642
Number of pages6
JournalEuropean Journal of Cardiovascular Prevention and Rehabilitation
Volume17
Issue number6
DOIs
Publication statusPublished - Dec 2010

Fingerprint

Heart Failure
Exercise
Muscle Fatigue
Cachexia
Dyspnea
Endothelium
Reflex
Skeletal Muscle
Quality of Life
Lung
Therapeutics

Keywords

  • chronic heart failure
  • exercise testing
  • exercise tolerance
  • quality of life
  • rehabilitation

ASJC Scopus subject areas

  • Cardiology and Cardiovascular Medicine
  • Epidemiology

Cite this

Exercise intolerance in chronic heart failure : Mechanisms and therapies. Part i. / Piepoli, Massimo F.; Guazzi, Marco; Boriani, Giuseppe; Cicoira, Mariantonietta; Corrà, Ugo; Libera, Luciano Dalla; Emdin, Michele; Mele, Donato; Passino, Claudio; Vescovo, Giorgio; Vigorito, Carlo; Villani, Giovanni Q.; Agostoni, Piergiuseppe.

In: European Journal of Cardiovascular Prevention and Rehabilitation, Vol. 17, No. 6, 12.2010, p. 637-642.

Research output: Contribution to journalArticle

Piepoli, MF, Guazzi, M, Boriani, G, Cicoira, M, Corrà, U, Libera, LD, Emdin, M, Mele, D, Passino, C, Vescovo, G, Vigorito, C, Villani, GQ & Agostoni, P 2010, 'Exercise intolerance in chronic heart failure: Mechanisms and therapies. Part i', European Journal of Cardiovascular Prevention and Rehabilitation, vol. 17, no. 6, pp. 637-642. https://doi.org/10.1097/HJR.0b013e3283361dc5
Piepoli, Massimo F. ; Guazzi, Marco ; Boriani, Giuseppe ; Cicoira, Mariantonietta ; Corrà, Ugo ; Libera, Luciano Dalla ; Emdin, Michele ; Mele, Donato ; Passino, Claudio ; Vescovo, Giorgio ; Vigorito, Carlo ; Villani, Giovanni Q. ; Agostoni, Piergiuseppe. / Exercise intolerance in chronic heart failure : Mechanisms and therapies. Part i. In: European Journal of Cardiovascular Prevention and Rehabilitation. 2010 ; Vol. 17, No. 6. pp. 637-642.
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