Abstract
Muscular fatigue and dyspnoea on exertion are among the most common symptoms in chronic heart failure; however their origin is still poorly understood. Several studies have shown that cardiac dysfunction alone cannot fully explain their origin, but the contribution of the multiorgan failure present in this syndrome must be highlighted. We aimed to summarize the existing evidence and the most controversial aspects of the complex interplay of different factors involved in the symptom generation. In the first part of the review, six key factors were revised (the heart, the lung, the skeletal muscle, the hormonal changes, the O2 delivery to the periphery, the endothelium). In this second part, the role of the excitatory reflexes and the cardiac cachexia are presented. Finally, potential therapeutic implications are discussed here. We believe that a better knowledge of the pathophysiology of this syndrome may contribute to the management of the patients and to the improvement in their stress tolerance and quality of life.
| Original language | English |
|---|---|
| Pages (from-to) | 643-648 |
| Number of pages | 6 |
| Journal | European Journal of Cardiovascular Prevention and Rehabilitation |
| Volume | 17 |
| Issue number | 6 |
| DOIs | |
| Publication status | Published - Dec 2010 |
Fingerprint
Keywords
- chronic heart failure
- exercise testing
- exercise tolerance
- quality of life
- rehabilitation
ASJC Scopus subject areas
- Cardiology and Cardiovascular Medicine
- Epidemiology
Cite this
Exercise intolerance in chronic heart failure : Mechanisms and therapies. Part II. / Piepoli, Massimo F.; Guazzi, Marco; Boriani, Giuseppe; Cicoira, Mariantonietta; Corrà, Ugo; Libera, Luciano Dalla; Emdin, Michele; Mele, Donato; Passino, Claudio; Vescovo, Giorgio; Vigorito, Carlo; Villani, Giovanni; Agostoni, Piergiuseppe.
In: European Journal of Cardiovascular Prevention and Rehabilitation, Vol. 17, No. 6, 12.2010, p. 643-648.Research output: Contribution to journal › Article
}
TY - JOUR
T1 - Exercise intolerance in chronic heart failure
T2 - Mechanisms and therapies. Part II
AU - Piepoli, Massimo F.
AU - Guazzi, Marco
AU - Boriani, Giuseppe
AU - Cicoira, Mariantonietta
AU - Corrà, Ugo
AU - Libera, Luciano Dalla
AU - Emdin, Michele
AU - Mele, Donato
AU - Passino, Claudio
AU - Vescovo, Giorgio
AU - Vigorito, Carlo
AU - Villani, Giovanni
AU - Agostoni, Piergiuseppe
PY - 2010/12
Y1 - 2010/12
N2 - Muscular fatigue and dyspnoea on exertion are among the most common symptoms in chronic heart failure; however their origin is still poorly understood. Several studies have shown that cardiac dysfunction alone cannot fully explain their origin, but the contribution of the multiorgan failure present in this syndrome must be highlighted. We aimed to summarize the existing evidence and the most controversial aspects of the complex interplay of different factors involved in the symptom generation. In the first part of the review, six key factors were revised (the heart, the lung, the skeletal muscle, the hormonal changes, the O2 delivery to the periphery, the endothelium). In this second part, the role of the excitatory reflexes and the cardiac cachexia are presented. Finally, potential therapeutic implications are discussed here. We believe that a better knowledge of the pathophysiology of this syndrome may contribute to the management of the patients and to the improvement in their stress tolerance and quality of life.
AB - Muscular fatigue and dyspnoea on exertion are among the most common symptoms in chronic heart failure; however their origin is still poorly understood. Several studies have shown that cardiac dysfunction alone cannot fully explain their origin, but the contribution of the multiorgan failure present in this syndrome must be highlighted. We aimed to summarize the existing evidence and the most controversial aspects of the complex interplay of different factors involved in the symptom generation. In the first part of the review, six key factors were revised (the heart, the lung, the skeletal muscle, the hormonal changes, the O2 delivery to the periphery, the endothelium). In this second part, the role of the excitatory reflexes and the cardiac cachexia are presented. Finally, potential therapeutic implications are discussed here. We believe that a better knowledge of the pathophysiology of this syndrome may contribute to the management of the patients and to the improvement in their stress tolerance and quality of life.
KW - chronic heart failure
KW - exercise testing
KW - exercise tolerance
KW - quality of life
KW - rehabilitation
UR - http://www.scopus.com/inward/record.url?scp=79851499475&partnerID=8YFLogxK
UR - http://www.scopus.com/inward/citedby.url?scp=79851499475&partnerID=8YFLogxK
U2 - 10.1097/HJR.0b013e32833f3aa5
DO - 10.1097/HJR.0b013e32833f3aa5
M3 - Article
C2 - 21217245
AN - SCOPUS:79851499475
VL - 17
SP - 643
EP - 648
JO - European Journal of Cardiovascular Prevention and Rehabilitation
JF - European Journal of Cardiovascular Prevention and Rehabilitation
SN - 1741-8267
IS - 6
ER -