Exercise performance after standard rehabilitation in COPD patients with lung hyperinflation

Ernesto Crisafulli, Elena Venturelli, Gianluca Biscione, Guido Vagheggini, Andrea Iattoni, Sasha Lucic, Nicolino Ambrosino, Franco Pasqua, Alfredo Cesario, Enrico Maria Clini

Research output: Contribution to journalArticle

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Abstract

The role of pulmonary rehabilitation (PR) in COPD patients with lung hyperinflation has not yet been fully investigated. We retrospectively evaluated the effect of a standard PR course on exercise tolerance and symptoms according to the presence or absence of associated lung hyperinflation, as defined by lung function parameters in three Italian rehabilitation centres. In a cohort of 823 COPD patients (age 71 ± 8 years, FEV1 56 ± 18% pred.) we have systematically recorded: changes ({increment}) in 6-minute walking test (6MWD) as the primary outcome; dyspnoea (D); muscle fatigue (F); SO2nadir during effort; perceived breathlessness score (MRC); and specific health-related quality of life (SGRQ). Outcomes were compared between patients with lung hyperinflation (n = 283, LH) or without (n = 540 No-LH). Groups were comparable for age, body mass index, baseline exercise tolerance, and breathlessness. {increment}-6MWD (+72 ± 47 vs. +62 ± 42 m, p <0.05); {increment}-D (-2.3 ± 1.7 vs. -1.9 ± 1.3 point, p <0.05) and {increment}-SO2nadir (+1.4 ± 3.0 and +0.5 ± 3.3 point, p <0.05) were greater in LH than in No-LH. Using a multivariate linear regression model, {increment}-6MWD in the LH group significantly correlated with lower functional residual capacity (p = 0.021) and baseline 6MWD (p = 0.004). Tolerance, gas exchange and perceived symptoms during effort are the parameters that gain a significant benefit from standard rehabilitation in COPD patients with a lung hyperinflation condition.

Original languageEnglish
Pages (from-to)23-31
Number of pages9
JournalInternal and Emergency Medicine
Volume9
Issue number1
DOIs
Publication statusPublished - Feb 2014

Fingerprint

Chronic Obstructive Pulmonary Disease
Rehabilitation
Exercise
Lung
Dyspnea
Exercise Tolerance
Linear Models
Functional Residual Capacity
Muscle Fatigue
Rehabilitation Centers
Walking
Body Mass Index
Gases
Quality of Life

Keywords

  • COPD
  • Exercise
  • Lung hyperinflation
  • Rehabilitation

ASJC Scopus subject areas

  • Emergency Medicine
  • Internal Medicine
  • Medicine(all)

Cite this

Crisafulli, E., Venturelli, E., Biscione, G., Vagheggini, G., Iattoni, A., Lucic, S., ... Clini, E. M. (2014). Exercise performance after standard rehabilitation in COPD patients with lung hyperinflation. Internal and Emergency Medicine, 9(1), 23-31. https://doi.org/10.1007/s11739-011-0727-z

Exercise performance after standard rehabilitation in COPD patients with lung hyperinflation. / Crisafulli, Ernesto; Venturelli, Elena; Biscione, Gianluca; Vagheggini, Guido; Iattoni, Andrea; Lucic, Sasha; Ambrosino, Nicolino; Pasqua, Franco; Cesario, Alfredo; Clini, Enrico Maria.

In: Internal and Emergency Medicine, Vol. 9, No. 1, 02.2014, p. 23-31.

Research output: Contribution to journalArticle

Crisafulli, E, Venturelli, E, Biscione, G, Vagheggini, G, Iattoni, A, Lucic, S, Ambrosino, N, Pasqua, F, Cesario, A & Clini, EM 2014, 'Exercise performance after standard rehabilitation in COPD patients with lung hyperinflation', Internal and Emergency Medicine, vol. 9, no. 1, pp. 23-31. https://doi.org/10.1007/s11739-011-0727-z
Crisafulli, Ernesto ; Venturelli, Elena ; Biscione, Gianluca ; Vagheggini, Guido ; Iattoni, Andrea ; Lucic, Sasha ; Ambrosino, Nicolino ; Pasqua, Franco ; Cesario, Alfredo ; Clini, Enrico Maria. / Exercise performance after standard rehabilitation in COPD patients with lung hyperinflation. In: Internal and Emergency Medicine. 2014 ; Vol. 9, No. 1. pp. 23-31.
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