Exercise performance after standard rehabilitation in COPD patients with lung hyperinflation

Ernesto Crisafulli, Elena Venturelli, Gianluca Biscione, Guido Vagheggini, Andrea Iattoni, Sasha Lucic, Nicolino Ambrosino, Franco Pasqua, Alfredo Cesario, Enrico Maria Clini

Research output: Contribution to journalArticlepeer-review


The role of pulmonary rehabilitation (PR) in COPD patients with lung hyperinflation has not yet been fully investigated. We retrospectively evaluated the effect of a standard PR course on exercise tolerance and symptoms according to the presence or absence of associated lung hyperinflation, as defined by lung function parameters in three Italian rehabilitation centres. In a cohort of 823 COPD patients (age 71 ± 8 years, FEV1 56 ± 18% pred.) we have systematically recorded: changes ({increment}) in 6-minute walking test (6MWD) as the primary outcome; dyspnoea (D); muscle fatigue (F); SO2nadir during effort; perceived breathlessness score (MRC); and specific health-related quality of life (SGRQ). Outcomes were compared between patients with lung hyperinflation (n = 283, LH) or without (n = 540 No-LH). Groups were comparable for age, body mass index, baseline exercise tolerance, and breathlessness. {increment}-6MWD (+72 ± 47 vs. +62 ± 42 m, p <0.05); {increment}-D (-2.3 ± 1.7 vs. -1.9 ± 1.3 point, p <0.05) and {increment}-SO2nadir (+1.4 ± 3.0 and +0.5 ± 3.3 point, p <0.05) were greater in LH than in No-LH. Using a multivariate linear regression model, {increment}-6MWD in the LH group significantly correlated with lower functional residual capacity (p = 0.021) and baseline 6MWD (p = 0.004). Tolerance, gas exchange and perceived symptoms during effort are the parameters that gain a significant benefit from standard rehabilitation in COPD patients with a lung hyperinflation condition.

Original languageEnglish
Pages (from-to)23-31
Number of pages9
JournalInternal and Emergency Medicine
Issue number1
Publication statusPublished - Feb 2014


  • COPD
  • Exercise
  • Lung hyperinflation
  • Rehabilitation

ASJC Scopus subject areas

  • Emergency Medicine
  • Internal Medicine
  • Medicine(all)


Dive into the research topics of 'Exercise performance after standard rehabilitation in COPD patients with lung hyperinflation'. Together they form a unique fingerprint.

Cite this