Exercise testing and 24-hour ambulatory blood pressure monitoring in children with Williams syndrome

U. Giordano, A. Turchetta, A. Giannotti, M. C. Digilio, F. Virgilii, A. Calzolari

Research output: Contribution to journalArticlepeer-review


The aim of the study was to assess work-load capacity and blood pressure (BP) response to treadmill exercise and 24-hour BP monitoring in children with Williams syndrome. Seventeen children were examined (8 males and 9 females) whose mean age was 13.8 ± 3.6 years. Six patients were on anti-hypertensive therapy. Each patient underwent clinical examination and measurement of BP at rest, during exercise, and during 24-hour monitoring. Two-dimensional echocardiogram and echo-Doppler of renal arteries were performed. The test was stopped for muscular fatique or reduced cooperation. The patients, when compared to a population of healthy children, had reduced total time of exercise (7.3 ± 1.9 vs 14.3 ± 2.6 min, p <0.001) and, at the same work-load, increased heart rate (167 ± 19 vs 145 ± 16 beats/min, p <0.001) and increased maximum systolic BP (146 ± 27 vs 128 ± 12 mmHg, p = 0.01). Ambulatory blood pressure measurement values showed higher systolic blood pressure both during daytime and nighttime. Our study confirms that children and adolescents with Williams syndrome are at high risk for hypertension, probably related to the alterations of large arteries. The data relating to the synthesis of elastin may have a direct relationship to the compliance of the arterial system, leading to hypertension.

Original languageEnglish
Pages (from-to)509-511
Number of pages3
JournalPediatric Cardiology
Issue number6
Publication statusPublished - 2001


  • Ambulatory blood pressure measurement
  • Exercise
  • Hypertension
  • Williams syndrome

ASJC Scopus subject areas

  • Cardiology and Cardiovascular Medicine
  • Pediatrics, Perinatology, and Child Health


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