This study was designed to assess the effects of a long-term treatment (six months) with an oxprenolol-bencyclan combination on arterial blood pressure and cardiac function in hypertensive patients. Cardiac function was evaluated by means of exercise tolerance and echocardiographic recording. Oxprenolol-bencyclan effected a good control of arterial blood pressure values in 14 of 20 enrolled patients. Of the remaining six patients, two were excluded because of a poor control of arterial blood pressure, one on account of side effects, and three were considered dropouts. Work load after treatment rose from 73.3 ± 6.14 watt to 100.0 ± 4.4 watt (p <0.05) while systolic blood pressure at same work load was 201.6 ± 7.0 mmHg, before, and 168.3 ± 8.7 mmHg after the treatment (p <0.05). Echocardiographic parameters of left ventricular anatomy and function remained unchanged. Our results confirm that oxprenolol-bencyclan treatment may be safely employed in hypertensive patients in view of its unimportant negative cardiac inotropic effect.
|Number of pages||9|
|Journal||Current Therapeutic Research|
|Publication status||Published - 1983|
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