Exercise training improves cardiopulmonary and endothelial function in women with breast cancer: findings from the Diana-5 dietary intervention study

Francesco Giallauria, Alessandra Vitelli, Luigi Maresca, Maria Santucci De Magistris, Paolo Chiodini, Amalia Mattiello, Marco Gentile, Maria Mancini, Alessandra Grieco, Angelo Russo, Rosa Lucci, Giorgio Torella, Franco Berrino, Salvatore Panico, Carlo Vigorito

Research output: Contribution to journalArticlepeer-review

Abstract

To investigate whether exercise training (ET) improves cardiopulmonary and endothelial function in women with breast cancer (BC). Fifty-one female patients (aged between 39 and 72 years) with a history of primary invasive BC within the previous 5 years and enrolled in the Mediterranean diet-based DIANA (diet and androgens)-5 Trial were subdivided into 2 groups: an ET group (n = 25) followed a formal ET program of moderate intensity (3 session/week on a bicycle at 60–70 % VO2peak for 3 months, followed by one session/week until 1-year follow-up), while a control group (n = 26) did not perform any formal ET. At baseline and at 1-year follow-up, all patients underwent cardiopulmonary exercise stress test (CPET) and measurements of vascular endothelial function by peripheral artery tonometry (Reactive Hyperemia Index, RHI). There were no significant differences between the groups in baseline anthropometrical, BC characteristics, and metabolic profile. No differences in baseline CPET and RHI parameters were found. Peak oxygen consumption (VO2peak) significantly increased in ET group (from 12.4 ± 2.9 to 14.3 ± 3.3 mL/kg/min, p 2peak were correlated with changes in RHI (ΔVO2peak vs. ΔRHI: r = 0.47, p = 0.017). In BC survivors, ET program improves cardiopulmonary functional capacity and vascular endothelial function after 12 months. Whether these changes may favorably modulate some of the pathophysiological mechanisms implied in cancer evolution should be investigated.

Original languageEnglish
Pages (from-to)183-189
Number of pages7
JournalInternal and Emergency Medicine
Volume11
Issue number2
DOIs
Publication statusPublished - Mar 1 2016

Keywords

  • Breast cancer
  • Cancer
  • Cardiopulmonary exercise testing
  • Endothelial function
  • Exercise training

ASJC Scopus subject areas

  • Emergency Medicine
  • Internal Medicine

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