Exercise training improves exertional dyspnea in patients with COPD: Evidence of the role of mechanical factors

Francesco Gigliotti, Claudia Coli, Roberto Bianchi, Isabella Romagnoli, Barbara Lanini, Barbara Binazzi, Giorgio Scano

Research output: Contribution to journalArticle

83 Citations (Scopus)

Abstract

Background: To our knowledge, no data have been reported on the effects of exercise training (EXT) on central respiratory motor output or neuromuscular coupling (NMC) of the ventilatory pump, and their potential association with exertional dyspnea. Accurate assessment of these important clinical outcomes is integral to effective management of breathlessness of patients with COPD. Material and methods: Twenty consecutive patients with stable moderate-to-severe COPD were tested at 6-week intervals at baseline, after a nonintervention control period (pre-EXT), and after EXT. Patients entered an outpatient pulmonary rehabilitation program involving regular exercise on a bicycle. Incremental symptom-limited exercise testing (1-min increments of 10 W) was performed on an electronically braked cycle ergometer. Oxygen uptake (VO2), carbon dioxide output (VCO2), minute ventilation (VE), time, and volume components of the respiratory cycle and, in six patients, esophageal pressure swings (Pessw), both as actual values and as percentage of maximal (most negative in sign) esophageal pressure during sniff maneuver (Pessn), were measured continuously over the runs. Exertional dyspnea and leg effort were evaluated by administering a Borg scale. Results: Measurements at baseline and pre-EXT were similar. Significant increase in exercise capacity was found in response to EXT: (1) peak work rate (WR), VO2, VCO2, VE, tidal volume (VT), and heart rate increased, while peak exertional dyspnea and leg effort did not significantly change; (2) exertional dyspnea/VO2 and exertional dyspnea/VCO2 decreased while VE/VO2 and VE/VCO2 remained unchanged. The slope of both exertional dyspnea and leg effort relative to VE fell significantly after EXT; (3) at standardized WR, VE, and VCO2, exertional dyspnea and leg effort decreased while inspiratory capacity (IC) increased. Decrease in VE was accomplished primarily by decrease in respiratory rate (RR) and increase in both inspiratory time (TI) and expiratory time; VT slightly increased, while inspiratory drive (VT/TI) and duty cycle (TI/total time of the respiratory cycle) remained unchanged. The decrease in Pessw and the increase in VT were associated with lower exertional dyspnea after EXT; (4) at standardized VE, VT, RR, and IC, Pessw and Pessw(%Pessn)/VT remained unchanged while exertional dyspnea and leg effort decreased with EXT. Conclusion: In conclusion, increases in NMC, aerobic capacity, and tolerance to dyspnogenic stimuli and possibly breathing retraining are likely to contribute to the relief of both exertional dyspnea and leg effort after EXT.

Original languageEnglish
Pages (from-to)1794-1802
Number of pages9
JournalChest
Volume123
Issue number6
DOIs
Publication statusPublished - Jun 1 2003

Fingerprint

Dyspnea
Chronic Obstructive Pulmonary Disease
Exercise
Ventilation
Tidal Volume
Leg
Pressure
Inspiratory Capacity
Respiratory Rate
Carbon Dioxide
Respiration
Outpatients
Rehabilitation
Heart Rate
Oxygen
Lung

Keywords

  • COPD
  • Dyspnea
  • Exercise training
  • Respiratory mechanics

ASJC Scopus subject areas

  • Pulmonary and Respiratory Medicine

Cite this

Exercise training improves exertional dyspnea in patients with COPD : Evidence of the role of mechanical factors. / Gigliotti, Francesco; Coli, Claudia; Bianchi, Roberto; Romagnoli, Isabella; Lanini, Barbara; Binazzi, Barbara; Scano, Giorgio.

In: Chest, Vol. 123, No. 6, 01.06.2003, p. 1794-1802.

Research output: Contribution to journalArticle

Gigliotti, Francesco ; Coli, Claudia ; Bianchi, Roberto ; Romagnoli, Isabella ; Lanini, Barbara ; Binazzi, Barbara ; Scano, Giorgio. / Exercise training improves exertional dyspnea in patients with COPD : Evidence of the role of mechanical factors. In: Chest. 2003 ; Vol. 123, No. 6. pp. 1794-1802.
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T2 - Evidence of the role of mechanical factors

AU - Gigliotti, Francesco

AU - Coli, Claudia

AU - Bianchi, Roberto

AU - Romagnoli, Isabella

AU - Lanini, Barbara

AU - Binazzi, Barbara

AU - Scano, Giorgio

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N2 - Background: To our knowledge, no data have been reported on the effects of exercise training (EXT) on central respiratory motor output or neuromuscular coupling (NMC) of the ventilatory pump, and their potential association with exertional dyspnea. Accurate assessment of these important clinical outcomes is integral to effective management of breathlessness of patients with COPD. Material and methods: Twenty consecutive patients with stable moderate-to-severe COPD were tested at 6-week intervals at baseline, after a nonintervention control period (pre-EXT), and after EXT. Patients entered an outpatient pulmonary rehabilitation program involving regular exercise on a bicycle. Incremental symptom-limited exercise testing (1-min increments of 10 W) was performed on an electronically braked cycle ergometer. Oxygen uptake (VO2), carbon dioxide output (VCO2), minute ventilation (VE), time, and volume components of the respiratory cycle and, in six patients, esophageal pressure swings (Pessw), both as actual values and as percentage of maximal (most negative in sign) esophageal pressure during sniff maneuver (Pessn), were measured continuously over the runs. Exertional dyspnea and leg effort were evaluated by administering a Borg scale. Results: Measurements at baseline and pre-EXT were similar. Significant increase in exercise capacity was found in response to EXT: (1) peak work rate (WR), VO2, VCO2, VE, tidal volume (VT), and heart rate increased, while peak exertional dyspnea and leg effort did not significantly change; (2) exertional dyspnea/VO2 and exertional dyspnea/VCO2 decreased while VE/VO2 and VE/VCO2 remained unchanged. The slope of both exertional dyspnea and leg effort relative to VE fell significantly after EXT; (3) at standardized WR, VE, and VCO2, exertional dyspnea and leg effort decreased while inspiratory capacity (IC) increased. Decrease in VE was accomplished primarily by decrease in respiratory rate (RR) and increase in both inspiratory time (TI) and expiratory time; VT slightly increased, while inspiratory drive (VT/TI) and duty cycle (TI/total time of the respiratory cycle) remained unchanged. The decrease in Pessw and the increase in VT were associated with lower exertional dyspnea after EXT; (4) at standardized VE, VT, RR, and IC, Pessw and Pessw(%Pessn)/VT remained unchanged while exertional dyspnea and leg effort decreased with EXT. Conclusion: In conclusion, increases in NMC, aerobic capacity, and tolerance to dyspnogenic stimuli and possibly breathing retraining are likely to contribute to the relief of both exertional dyspnea and leg effort after EXT.

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