TY - JOUR
T1 - Exercise training improves heart rate recovery in women with breast cancer
AU - Giallauria, Francesco
AU - Maresca, Luigi
AU - Vitelli, Alessandra
AU - Santucci de Magistris, Maria
AU - Chiodini, Paolo
AU - Mattiello, Amalia
AU - Gentile, Marco
AU - Mancini, Maria
AU - Grieco, Alessandra
AU - Russo, Angelo
AU - Lucci, Rosa
AU - Torella, Giorgio
AU - Berrino, Franco
AU - Panico, Salvatore
AU - Vigorito, Carlo
PY - 2015/12/6
Y1 - 2015/12/6
N2 - Purpose: To determine whether exercise training improves autonomic function in women with breast cancer (BC). Methods: Fifty-one patients (aged between 39 and 72 years) with a history of primary invasive BC within the previous 5 years and enrolled in the Mediterranean diet-based DIANA (Diet and Androgens)-5 Trial were subdivided in two groups: a ET group (n = 25) followed a formal ET program of moderate intensity (3 session/week on a bicycle at 60–70% VO2peak for 3 months, followed by one session/week until 1-year follow-up), while a control group (n = 26) did not perform any formal ET. At baseline and after 1-year, all patients underwent cardiopulmonary exercise stress test (CPET). Heart rate recovery (HRR) was calculated as the difference between heart rate at peak exercise and heart rate at first minute of the cool-down period. Results: There were no significant differences between groups in baseline anthropometrical, BC characteristics, metabolic profile, CPET parameters and HRR. Compared to controls, at 1-year follow-up ET group showed a significant improvement in VO2peak (from 12.6 ± 3.0 to 14.5 ± 3.3 ml/kg/min, p 2peak (r = 0.58, p = 0.002). Conclusions: Moderate intensity exercise training in BC survivors is associated with improvement of autonomic function. Whether the improvement of sympatho-vagal balance may favorably modulate some of the pathophysiological mechanisms implied in cancer evolution need further investigation.
AB - Purpose: To determine whether exercise training improves autonomic function in women with breast cancer (BC). Methods: Fifty-one patients (aged between 39 and 72 years) with a history of primary invasive BC within the previous 5 years and enrolled in the Mediterranean diet-based DIANA (Diet and Androgens)-5 Trial were subdivided in two groups: a ET group (n = 25) followed a formal ET program of moderate intensity (3 session/week on a bicycle at 60–70% VO2peak for 3 months, followed by one session/week until 1-year follow-up), while a control group (n = 26) did not perform any formal ET. At baseline and after 1-year, all patients underwent cardiopulmonary exercise stress test (CPET). Heart rate recovery (HRR) was calculated as the difference between heart rate at peak exercise and heart rate at first minute of the cool-down period. Results: There were no significant differences between groups in baseline anthropometrical, BC characteristics, metabolic profile, CPET parameters and HRR. Compared to controls, at 1-year follow-up ET group showed a significant improvement in VO2peak (from 12.6 ± 3.0 to 14.5 ± 3.3 ml/kg/min, p 2peak (r = 0.58, p = 0.002). Conclusions: Moderate intensity exercise training in BC survivors is associated with improvement of autonomic function. Whether the improvement of sympatho-vagal balance may favorably modulate some of the pathophysiological mechanisms implied in cancer evolution need further investigation.
KW - Autonomic function
KW - Breast cancer
KW - Cancer
KW - Cardiopulmonary exercise testing
KW - Exercise training
KW - Heart rate recovery
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U2 - 10.1186/s40064-015-1179-0
DO - 10.1186/s40064-015-1179-0
M3 - Article
AN - SCOPUS:84938570034
VL - 4
JO - SpringerPlus
JF - SpringerPlus
SN - 2193-1801
IS - 1
M1 - 388
ER -