Exercise training in obese older adults prevents increase in bone turnover and attenuates decrease in hip bone mineral density induced by weight loss despite decline in bone-active hormones

Krupa Shah, Reina Armamento-Villareal, Nehu Parimi, Suresh Chode, David R. Sinacore, Tiffany N. Hilton, Nicola Napoli, Clifford Qualls, Dennis T. Villareal

Research output: Contribution to journalArticle

94 Citations (Scopus)

Abstract

Weight loss therapy to improve health in obese older adults is controversial because it causes further bone loss. Therefore, it is recommended that weight loss therapy should include an intervention such as exercise training (ET) to minimize bone loss. The purpose of this study was to determine the independent and combined effects of weight loss and ET on bone metabolism in relation to bone mineral density (BMD) in obese older adults. One-hundred-seven older (age >65 years) obese (body mass index [BMI] ≥30 kg/m 2) adults were randomly assigned to a control group, diet group, exercise group, and diet-exercise group for 1 year. Body weight decreased in the diet (-9.6%) and diet-exercise (-9.4%) groups, not in the exercise (-1%) and control (-0.2%) groups (between-group p <0.001). However, despite comparable weight loss, bone loss at the total hip was relatively less in the diet-exercise group (-1.1%) than in the diet group (-2.6%), whereas BMD increased in the exercise group (1.5%) (between-group p <0.001). Serum C-terminal telopeptide (CTX) and osteocalcin concentrations increased in the diet group (31% and 24%, respectively), whereas they decreased in the exercise group (-13% and -15%, respectively) (between-group p <0.001). In contrast, similar to the control group, serum CTX and osteocalcin concentrations did not change in the diet-exercise group. Serum procollagen propeptide concentrations decreased in the exercise group (-15%) compared with the diet group (9%) (p = 0.04). Serum leptin and estradiol concentrations decreased in the diet (-25% and -15%, respectively) and diet-exercise (-38% and -13%, respectively) groups, not in the exercise and control groups (between-group p = 0.001). Multivariate analyses revealed that changes in lean body mass (β = 0.33), serum osteocalcin (β = -0.24), and one-repetition maximum (1-RM) strength (β = 0.23) were independent predictors of changes in hip BMD (all p <0.05). In conclusion, the addition of ET to weight loss therapy among obese older adults prevents weight loss-induced increase in bone turnover and attenuates weight loss-induced reduction in hip BMD despite weight loss-induced decrease in bone-active hormones. © 2011 American Society for Bone and Mineral Research

Original languageEnglish
Pages (from-to)2851-2859
Number of pages9
JournalJournal of Bone and Mineral Research
Volume26
Issue number12
DOIs
Publication statusPublished - Dec 2011

Fingerprint

Pelvic Bones
Bone Remodeling
Bone Density
Weight Loss
Hormones
Exercise
Diet
Bone and Bones
Osteocalcin
Serum
Control Groups
Procollagen
Leptin
Hip
Estradiol
Body Mass Index
Therapeutics

Keywords

  • BONE METABOLISM
  • EXERCISE
  • OBESE OLDER ADULTS
  • WEIGHT LOSS

ASJC Scopus subject areas

  • Orthopedics and Sports Medicine
  • Endocrinology, Diabetes and Metabolism

Cite this

Exercise training in obese older adults prevents increase in bone turnover and attenuates decrease in hip bone mineral density induced by weight loss despite decline in bone-active hormones. / Shah, Krupa; Armamento-Villareal, Reina; Parimi, Nehu; Chode, Suresh; Sinacore, David R.; Hilton, Tiffany N.; Napoli, Nicola; Qualls, Clifford; Villareal, Dennis T.

In: Journal of Bone and Mineral Research, Vol. 26, No. 12, 12.2011, p. 2851-2859.

Research output: Contribution to journalArticle

Shah, Krupa ; Armamento-Villareal, Reina ; Parimi, Nehu ; Chode, Suresh ; Sinacore, David R. ; Hilton, Tiffany N. ; Napoli, Nicola ; Qualls, Clifford ; Villareal, Dennis T. / Exercise training in obese older adults prevents increase in bone turnover and attenuates decrease in hip bone mineral density induced by weight loss despite decline in bone-active hormones. In: Journal of Bone and Mineral Research. 2011 ; Vol. 26, No. 12. pp. 2851-2859.
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AU - Chode, Suresh

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