Objective. Exfoliative cytology, a well-known diagnostic technique applied in various fields of medicine, was used to determine the efficacy of calcipotriol in psoriasis. Experimental design. Open study - Comparison with cytologic results previously obtained with other antipsoriatic drugs (methotrexate, etretinate, cyclosporin A). Environment. A university Dermatology department with a laboratory for cytologic preparations. Patients. Twenty-eight patients (20 males, 8 females), aged 18 to 65 (mean 48), with mild to moderate chronic relapsing psoriasis en plaques. Methods. Cells for cytologic examination are provided through application of biadhesive tape to psoriatic plaques, then coloured with Giemsa, and finally observed at 1000x. Results. After 3 weeks, the number of parakeratotic and halo-cells, which are markers of active disease, had markedly decreased. These results confirmed the effectiveness of calcipotriol in regulating the epidermal turn-over, especially if compared to the cytologic methotrexate, etretinate, and cyclosporin A.
|Translated title of the contribution||Exfoliative cytology of psoriasis. Effects of calcipotriol|
|Number of pages||5|
|Journal||Giornale Italiano di Dermatologia e Venereologia|
|Publication status||Published - 1995|
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