Exhaled and nasal nitric oxide measurement in the evaluation of chronic cough

Mauro Maniscalco, Salvatore Fuschillo, Carlo Gaudiosi, Alberto De Felice, Michele Martucci, Andrea Motta

Research output: Contribution to journalReview articlepeer-review


Chronic cough is one of the most common and troublesome nonspecific respiratory symptom for which patients seek a general practitioner and specialist advice. It is conventionally defined as a cough lasting for more than 8 weeks. Exhaled nitric oxide has proven to be a specific biomarker capable to discriminate between differential diagnoses of chronic cough and simultaneously provide information about the response to specific treatment. In this review, we will discuss the potential use of exhaled and nasal nitric oxide in the diagnosis of chronic chough.

Original languageEnglish
Pages (from-to)19-23
Number of pages5
JournalNitric Oxide - Biology and Chemistry
Publication statusPublished - Feb 1 2019


  • Asthma/metabolism
  • Biomarkers/analysis
  • Breath Tests
  • Chronic Disease
  • Cough/metabolism
  • Exhalation
  • Humans
  • Nitric Oxide/analysis
  • Nose/chemistry


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