Exhaled Interleukine-6 and 8-isoprostane in chronic obstructive pulmonary disease: Effect of carbocysteine lysine salt monohydrate (SCMC-Lys)

Giovanna E. Carpagnano, O. Resta, Maria P. Foschino-Barbaro, Antonio Spanevello, Antonio Stefano, Giuseppe Di Gioia, Gaetano Serviddio, Enzo Gramiccioni

Research output: Contribution to journalArticle

Abstract

Chronic obstructive pulmonary disease (COPD) is characterized by an airways inflammation and by an enhanced generation of reactive oxygen species. The aim of our study was to assess the inflammation and the oxidative stress in airways of COPD patients with acute exacerbation of disease and in stability. Furthermore, we investigated the anti-inflammatory and antioxidant effects of 6 months treatment with carbocysteine lysine salt monohydrate (SCMC-Lys) in COPD. We studied 30 mild acute COPD, 10 mild stable COPD and 15 healthy subjects. 8-isoprostane and Interleukine-6 were measured in their breath condensate through immunoassay. Significantly higher concentrations of exhaled 8-isoprostane and Interleukine-6 were found in acute COPD patients compared to stable COPD and healthy controls (21.8±5.1 vs. 13.2±2.0 vs. 4.7±1.8 pg/ml and 7.4±0.9 vs. 5.8±0.2 vs. 2.7±0.6 pg/ml, p

Original languageEnglish
Pages (from-to)169-175
Number of pages7
JournalEuropean Journal of Pharmacology
Volume505
Issue number1-3
DOIs
Publication statusPublished - Nov 28 2004

Keywords

  • 8-isoprostane
  • Breath condensate
  • COPD
  • Interleukin-6
  • SCMC-Lys (Carbocysteine lysine salt monohydrate)

ASJC Scopus subject areas

  • Cellular and Molecular Neuroscience
  • Pharmacology

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