Exhaled nitric oxide in systemic sclerosis: Relationships with lung involvement and pulmonary hypertension

Giovanni Rolla, Paola Colagrande, Ermanno Scappaticci, Giovanni Chiavassa, Luca Dutto, Silvana Cannizzo, Caterina Bucca, Mara Morello, Serena Bergerone, Daniela Bardini, Alessandro Zaccagna, Paolo Puiatti, Cesare Fava, Giancarlo Cortese

Research output: Contribution to journalArticlepeer-review


Objective. To measure nitric oxide (NO) concentration in exhaled air of patients with systemic sclerosis (SSc) and to investigate its relationships with lung involvement, complicated or not by pulmonary hypertension (PH). Methods. Exhaled NO was measured by chemiluminescence in 47 patients with SSc (16 with PH) and in 30 controls. All the patients underwent Doppler echocardiography to assess pulmonary artery pressure (PAP), lung function tests, and thin section computed tomographic scans of the lung to quantify the extent of fibrosing alveolitis. Results. Exhaled NO levels were higher in patients with SSc (16.6 ± 9.1 ppb), particularly those with interstitial lung disease (ILD) (18.3 ± 10.4 ppb), compared to controls (9.9 ± 2.9 ppb; p <0.0001). In patients with PH, exhaled NO was less than in patients without PH (10.7 ± 5.9 vs 19.6 ± 9 ppb, respectively; p <0.001), and patients with PH without ILD had even lower exhaled NO than patients with PH and ILD (6.6 ± 1.1 vs 12.6 ± 6.3 ppb; p = 0.004). There was an inverse correlation between PAP and exhaled NO (r = -0.53, p = 0.004). Exhaled NO was not correlated to age, disease duration, current therapy, or form of disease (limited or diffuse). Conclusion. The increased concentration of exhaled NO in patients with SSc may reflect respiratory tract inflammation. The relatively low value of exhaled NO in patients with PH and the negative correlation between PAP and exhaled NO suggest the important role of NO in regulating pulmonary vascular resistance in patients with SSc.

Original languageEnglish
Pages (from-to)1693-1698
Number of pages6
JournalJournal of Rheumatology
Issue number7
Publication statusPublished - 2000


  • Exhaled nitric oxide
  • Pulmonary hypertension
  • Systemic sclerosis

ASJC Scopus subject areas

  • Rheumatology
  • Immunology


Dive into the research topics of 'Exhaled nitric oxide in systemic sclerosis: Relationships with lung involvement and pulmonary hypertension'. Together they form a unique fingerprint.

Cite this