Existence of a genetic risk factor on chromosome 5q in Italian Coeliac disease families

L. Greco; M. C. Babron; G. R. Corazza; S. Percopo; R. Sica; F. Clot; M. C. Fulchignoni-Lataud; P. Zavattari; P. Momigliano-Richiardi; G. Casari; P. Gasparini; R. Tosi; V. Mantovani; S. De Virgiliis; G. Iacono; A. D'Alfonso; H. Selinger-Leneman; A. Lemainque; J. L. Serre; F. Clerget-Darpoux

Existence of a genetic risk factor on chromosome 5q in Italian Coeliac disease families

L. Greco, M. C. Babron, G. R. Corazza, S. Percopo, R. Sica, F. Clot, M. C. Fulchignoni-Lataud, P. Zavattari, P. Momigliano-Richiardi, G. Casari, P. Gasparini, R. Tosi, V. Mantovani, S. De Virgiliis, G. Iacono, A. D'Alfonso, H. Selinger-Leneman, A. Lemainque, J. L. Serre, F. Clerget-Darpoux

Research output: Contribution to journal › Article › peer-review

Abstract

Coeliac disease (CD) is a malabsorptive disorder of the small intestine resulting from ingestion of gluten. The HLA risk factors involved in CD are well known but do not explain the whole genetic susceptibility. Several regions of potential linkage on chromosomes 3q, 5q, 10q, 11q, 15q and 19q have already been reported in the literature. These six regions were analyzed with the Maximum Lod Score method on a dense set of markers. A new sample of 89 Italian sibpairs was available for study. There was no evidence for linkage for any of the regions tested, except for chromosome 5q. For this region, our data, as well as a sample of 93 sibpairs from our first genome screen (Greco et al. 1998), are compatible with the presence of a risk factor for CD with a moderate effect.

Original language	English
Pages (from-to)	35-41
Number of pages	7
Journal	Annals of Human Genetics
Issue number	1
Publication status	Published - Jan 2001

ASJC Scopus subject areas

Genetics(clinical)
Genetics

Cite this

Greco, L., Babron, M. C., Corazza, G. R., Percopo, S., Sica, R., Clot, F., Fulchignoni-Lataud, M. C., Zavattari, P., Momigliano-Richiardi, P., Casari, G., Gasparini, P., Tosi, R., Mantovani, V., De Virgiliis, S., Iacono, G., D'Alfonso, A., Selinger-Leneman, H., Lemainque, A., Serre, J. L., & Clerget-Darpoux, F. (2001). Existence of a genetic risk factor on chromosome 5q in Italian Coeliac disease families. Annals of Human Genetics, (1), 35-41.

Greco, L, Babron, MC, Corazza, GR, Percopo, S, Sica, R, Clot, F, Fulchignoni-Lataud, MC, Zavattari, P, Momigliano-Richiardi, P, Casari, G , Gasparini, P, Tosi, R, Mantovani, V, De Virgiliis, S, Iacono, G, D'Alfonso, A, Selinger-Leneman, H, Lemainque, A, Serre, JL & Clerget-Darpoux, F 2001, 'Existence of a genetic risk factor on chromosome 5q in Italian Coeliac disease families', Annals of Human Genetics, no. 1, pp. 35-41.

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abstract = "Coeliac disease (CD) is a malabsorptive disorder of the small intestine resulting from ingestion of gluten. The HLA risk factors involved in CD are well known but do not explain the whole genetic susceptibility. Several regions of potential linkage on chromosomes 3q, 5q, 10q, 11q, 15q and 19q have already been reported in the literature. These six regions were analyzed with the Maximum Lod Score method on a dense set of markers. A new sample of 89 Italian sibpairs was available for study. There was no evidence for linkage for any of the regions tested, except for chromosome 5q. For this region, our data, as well as a sample of 93 sibpairs from our first genome screen (Greco et al. 1998), are compatible with the presence of a risk factor for CD with a moderate effect.",

author = "L. Greco and Babron, {M. C.} and Corazza, {G. R.} and S. Percopo and R. Sica and F. Clot and Fulchignoni-Lataud, {M. C.} and P. Zavattari and P. Momigliano-Richiardi and G. Casari and P. Gasparini and R. Tosi and V. Mantovani and {De Virgiliis}, S. and G. Iacono and A. D'Alfonso and H. Selinger-Leneman and A. Lemainque and Serre, {J. L.} and F. Clerget-Darpoux",

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AU - Greco, L.

AU - Babron, M. C.

AU - Corazza, G. R.

AU - Percopo, S.

AU - Sica, R.

AU - Clot, F.

AU - Fulchignoni-Lataud, M. C.

AU - Zavattari, P.

AU - Momigliano-Richiardi, P.

AU - Casari, G.

AU - Gasparini, P.

AU - Tosi, R.

AU - Mantovani, V.

AU - De Virgiliis, S.

AU - Iacono, G.

AU - D'Alfonso, A.

AU - Selinger-Leneman, H.

AU - Lemainque, A.

AU - Serre, J. L.

AU - Clerget-Darpoux, F.

PY - 2001/1

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N2 - Coeliac disease (CD) is a malabsorptive disorder of the small intestine resulting from ingestion of gluten. The HLA risk factors involved in CD are well known but do not explain the whole genetic susceptibility. Several regions of potential linkage on chromosomes 3q, 5q, 10q, 11q, 15q and 19q have already been reported in the literature. These six regions were analyzed with the Maximum Lod Score method on a dense set of markers. A new sample of 89 Italian sibpairs was available for study. There was no evidence for linkage for any of the regions tested, except for chromosome 5q. For this region, our data, as well as a sample of 93 sibpairs from our first genome screen (Greco et al. 1998), are compatible with the presence of a risk factor for CD with a moderate effect.

AB - Coeliac disease (CD) is a malabsorptive disorder of the small intestine resulting from ingestion of gluten. The HLA risk factors involved in CD are well known but do not explain the whole genetic susceptibility. Several regions of potential linkage on chromosomes 3q, 5q, 10q, 11q, 15q and 19q have already been reported in the literature. These six regions were analyzed with the Maximum Lod Score method on a dense set of markers. A new sample of 89 Italian sibpairs was available for study. There was no evidence for linkage for any of the regions tested, except for chromosome 5q. For this region, our data, as well as a sample of 93 sibpairs from our first genome screen (Greco et al. 1998), are compatible with the presence of a risk factor for CD with a moderate effect.

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Existence of a genetic risk factor on chromosome 5q in Italian Coeliac disease families

Abstract

ASJC Scopus subject areas

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