TY - JOUR
T1 - Existence of a genetic risk factor on chromosome 5q in Italian Coeliac disease families
AU - Greco, L.
AU - Babron, M. C.
AU - Corazza, G. R.
AU - Percopo, S.
AU - Sica, R.
AU - Clot, F.
AU - Fulchignoni-Lataud, M. C.
AU - Zavattari, P.
AU - Momigliano-Richiardi, P.
AU - Casari, G.
AU - Gasparini, P.
AU - Tosi, R.
AU - Mantovani, V.
AU - De Virgiliis, S.
AU - Iacono, G.
AU - D'Alfonso, A.
AU - Selinger-Leneman, H.
AU - Lemainque, A.
AU - Serre, J. L.
AU - Clerget-Darpoux, F.
PY - 2001/1
Y1 - 2001/1
N2 - Coeliac disease (CD) is a malabsorptive disorder of the small intestine resulting from ingestion of gluten. The HLA risk factors involved in CD are well known but do not explain the whole genetic susceptibility. Several regions of potential linkage on chromosomes 3q, 5q, 10q, 11q, 15q and 19q have already been reported in the literature. These six regions were analyzed with the Maximum Lod Score method on a dense set of markers. A new sample of 89 Italian sibpairs was available for study. There was no evidence for linkage for any of the regions tested, except for chromosome 5q. For this region, our data, as well as a sample of 93 sibpairs from our first genome screen (Greco et al. 1998), are compatible with the presence of a risk factor for CD with a moderate effect.
AB - Coeliac disease (CD) is a malabsorptive disorder of the small intestine resulting from ingestion of gluten. The HLA risk factors involved in CD are well known but do not explain the whole genetic susceptibility. Several regions of potential linkage on chromosomes 3q, 5q, 10q, 11q, 15q and 19q have already been reported in the literature. These six regions were analyzed with the Maximum Lod Score method on a dense set of markers. A new sample of 89 Italian sibpairs was available for study. There was no evidence for linkage for any of the regions tested, except for chromosome 5q. For this region, our data, as well as a sample of 93 sibpairs from our first genome screen (Greco et al. 1998), are compatible with the presence of a risk factor for CD with a moderate effect.
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M3 - Article
C2 - 11415521
AN - SCOPUS:0034744360
SP - 35
EP - 41
JO - Annals of Human Genetics
JF - Annals of Human Genetics
SN - 0003-4800
IS - 1
ER -