Exiting the Golgi complex

Maria Antonietta De Matteis, Alberto Luini

Research output: Contribution to journalArticlepeer-review


The composition and identity of cell organelles are dictated by the flux of lipids and proteins that they receive and lose through cytosolic exchange and membrane trafficking. The trans-Golgi network (TGN) is a major sorting centre for cell lipids and proteins at the crossroads of the endocytic and exocytic pathways; it has a complex dynamic structure composed of a network of tubular membranes that generate pleiomorphic carriers targeted to different destinations. Live-cell imaging combined with three-dimensional tomography has recently provided the temporal and topographical framework that allows the assembly of the numerous molecular machineries so far implicated in sorting and trafficking at the TGN.

Original languageEnglish
Pages (from-to)273-284
Number of pages12
JournalNature Reviews Molecular Cell Biology
Issue number4
Publication statusPublished - Apr 2008

ASJC Scopus subject areas

  • Molecular Biology
  • Cell Biology


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