Exocrine and endocrine modulation in common gastric carcinoma

Vincenzo Canzonieri, Cristina Colarossi, Laura Del Col, Tiziana Perin, Renato Talamini, Roberto Sigon, Renato Cannizzaro, Eleonora Aiello, Angela Buonadonna, Fabrizio Italia, Daniela Massi, Antonino Carbone, Lorenzo Memeo

Research output: Contribution to journalArticlepeer-review


Diagnostic and prognostic implications of endocrine differentiation were evaluated in 103 common gastric adenocarcinomas and undifferentiated carcinomas. Maturely differentiated exocrine and endocrine phenotypes were evaluated by using gastric exocrine and endocrine markers along with intestinal exocrine and endocrine markers. Immunohistochemical analysis revealed that 66 tumors (64%) were positive for generic endocrine markers such as chromogranin A and/or synaptophysin. The 14 patients with more than 20% tumor cells positive for at least 1 endocrine marker experienced a poorer prognosis than patients with no (n = 37) or 1% to 20% (n = 52) positivity. The 16 carcinomas expressing the maturely differentiated exocrine gastric phenotype significantly correlated with poorer outcome compared with carcinomas with mature exocrine intestinal (n = 22) or mixed/gastrointestinal (n = 64) phenotypes. Among tumors expressing chromogranin A and/or synaptophysin, the maturely differentiated endocrine gastric phenotype (n = 26) was a negative prognostic factor compared with mature endocrine intestinal (n = 21) and mixed/gastrointestinal (n = 5) phenotypes. Endocrine differentiation and maturely exocrine/endocrine gastric phenotypes are associated with an unfavorable prognosis and may identify subsets of patients for tailored therapy.

Original languageEnglish
Pages (from-to)712-721
Number of pages10
JournalAmerican Journal of Clinical Pathology
Issue number5
Publication statusPublished - May 2012


  • Endocrine differentiation
  • Endocrine phenotype
  • Exocrine phenotype
  • Gastric carcinoma
  • Neuroendocrine differentiation
  • Prognosis

ASJC Scopus subject areas

  • Pathology and Forensic Medicine


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