Abstract
In this study heparin (HE) was injected into the allantoic sac of chick embryo eggs at 5. 9, 14 days of incubation. 48 h after injection glycosaminoglyean (GAG) concentration was measured in the chorioallantoic membrane (CAM) in order to verify if HE-related CAM angiogenic activity previously demonstrated [Ribatti et al: Acta Anat 1987; 130: 257-263] might be correlated with changes in GAG concentration. The results showed that HE inoculation induced an increase of 3H-glucosamine incorporation into total GAGs in comparison to control CAMs. Furthermore, HE altered the balance between the GAG classes, and in particular it produced a significant increase in the accumulation of hyaluronic acid and heparan sulfate between 7 and 11 days of incubation in comparison to control CAMs.
Original language | English |
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Pages (from-to) | 181-185 |
Number of pages | 5 |
Journal | International journal of microcirculation, clinical and experimental / sponsored by the European Society for Microcirculation |
Volume | 15 |
Issue number | 4 |
DOIs | |
Publication status | Published - 1995 |
Keywords
- Angiogenesis
- Chorioallantoic membrane
- Glycosaminoglycans
- Heparin
ASJC Scopus subject areas
- Physiology
- Cardiology and Cardiovascular Medicine