Abstract
Introduction: Cell-to-cell communication is imperative for life and it is mediated by sending and receiving information via the secretion and subsequent receptor-mediated detection of biological molecules. Exosomes (EXs) secreted from cells to the extracellular environment play an important role in intercellular communication in normal and pathological conditions. Areas covered: New evidence indicates that tumor cells-derived EXs contribute to cancer progression through the modulation of tumor microenvironment. The exosomal heat shock protein 60 (HSP60) is very likely a key player in intercellular cross-talk, particularly during the progress of diseases, such as cancer. Many studies have focused on the extracellular roles played by HSP60 that pertain to cancer development and immune system stimulation. Our experimental data in vitro and in vivo demonstrated that HSP60 occurs on the surface of EXs secreted by tumour cells. Expert commentary: Exosomal HSP60 has great potential for clinical applications, as a ‘liquid biopsy’, including its use as biomarker for diagnostics, assessing prognosis, and monitoring disease progression and response to treatment, particularly in cancer.
| Original language | English |
|---|---|
| Pages (from-to) | 815-822 |
| Number of pages | 8 |
| Journal | Expert Review of Molecular Diagnostics |
| Volume | 17 |
| Issue number | 9 |
| DOIs | |
| Publication status | Published - Sep 2 2017 |
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Keywords
- Cancer
- Exosomes (EXs)
- Extracellular Vesicles (EVs)
- Heat Shock Protein 60 (HSP60)
- liquid biopsy
- theranostics
ASJC Scopus subject areas
- Pathology and Forensic Medicine
- Molecular Medicine
- Molecular Biology
- Genetics
Cite this
Exosomal HSP60 : a potentially useful biomarker for diagnosis, assessing prognosis, and monitoring response to treatment. / Caruso Bavisotto, Celeste; Cappello, Francesco; Macario, Alberto J.L.; Conway de Macario, Everly; Logozzi, Mariantonia; Fais, Stefano; Campanella, Claudia.
In: Expert Review of Molecular Diagnostics, Vol. 17, No. 9, 02.09.2017, p. 815-822.Research output: Contribution to journal › Review article
}
TY - JOUR
T1 - Exosomal HSP60
T2 - a potentially useful biomarker for diagnosis, assessing prognosis, and monitoring response to treatment
AU - Caruso Bavisotto, Celeste
AU - Cappello, Francesco
AU - Macario, Alberto J.L.
AU - Conway de Macario, Everly
AU - Logozzi, Mariantonia
AU - Fais, Stefano
AU - Campanella, Claudia
PY - 2017/9/2
Y1 - 2017/9/2
N2 - Introduction: Cell-to-cell communication is imperative for life and it is mediated by sending and receiving information via the secretion and subsequent receptor-mediated detection of biological molecules. Exosomes (EXs) secreted from cells to the extracellular environment play an important role in intercellular communication in normal and pathological conditions. Areas covered: New evidence indicates that tumor cells-derived EXs contribute to cancer progression through the modulation of tumor microenvironment. The exosomal heat shock protein 60 (HSP60) is very likely a key player in intercellular cross-talk, particularly during the progress of diseases, such as cancer. Many studies have focused on the extracellular roles played by HSP60 that pertain to cancer development and immune system stimulation. Our experimental data in vitro and in vivo demonstrated that HSP60 occurs on the surface of EXs secreted by tumour cells. Expert commentary: Exosomal HSP60 has great potential for clinical applications, as a ‘liquid biopsy’, including its use as biomarker for diagnostics, assessing prognosis, and monitoring disease progression and response to treatment, particularly in cancer.
AB - Introduction: Cell-to-cell communication is imperative for life and it is mediated by sending and receiving information via the secretion and subsequent receptor-mediated detection of biological molecules. Exosomes (EXs) secreted from cells to the extracellular environment play an important role in intercellular communication in normal and pathological conditions. Areas covered: New evidence indicates that tumor cells-derived EXs contribute to cancer progression through the modulation of tumor microenvironment. The exosomal heat shock protein 60 (HSP60) is very likely a key player in intercellular cross-talk, particularly during the progress of diseases, such as cancer. Many studies have focused on the extracellular roles played by HSP60 that pertain to cancer development and immune system stimulation. Our experimental data in vitro and in vivo demonstrated that HSP60 occurs on the surface of EXs secreted by tumour cells. Expert commentary: Exosomal HSP60 has great potential for clinical applications, as a ‘liquid biopsy’, including its use as biomarker for diagnostics, assessing prognosis, and monitoring disease progression and response to treatment, particularly in cancer.
KW - Cancer
KW - Exosomes (EXs)
KW - Extracellular Vesicles (EVs)
KW - Heat Shock Protein 60 (HSP60)
KW - liquid biopsy
KW - theranostics
UR - http://www.scopus.com/inward/record.url?scp=85027317913&partnerID=8YFLogxK
UR - http://www.scopus.com/inward/citedby.url?scp=85027317913&partnerID=8YFLogxK
U2 - 10.1080/14737159.2017.1356230
DO - 10.1080/14737159.2017.1356230
M3 - Review article
VL - 17
SP - 815
EP - 822
JO - Expert Review of Molecular Diagnostics
JF - Expert Review of Molecular Diagnostics
SN - 1473-7159
IS - 9
ER -