Exosome levels in human body fluids: A tumor marker by themselves?

Francesco Cappello, Mariantonia Logozzi, Claudia Campanella, Celeste Caruso Bavisotto, Antonio Marcilla, Francesca Properzi, Stefano Fais

Research output: Contribution to journalArticle

Abstract

Despite considerable research efforts, the finding of reliable tumor biomarkers remains challenging and unresolved. In recent years a novel diagnostic biomedical tool with high potential has been identified in extracellular nanovesicles or exosomes. They are released by the majority of the cells and contain detailed molecular information on the cell of origin including tumor hallmarks. Exosomes can be isolated from easy accessible body fluids, and most importantly, they can provide several biomarkers, with different levels of specificity. Recent clinical evidence shows that the levels of exosomes released into body fluids may themselves represent a predictive/diagnostic of tumors, discriminating cancer patients from healthy subjects. The aim of this review is to highlight these latest challenging findings to provide novel and groundbreaking ideas for successful tumor early diagnosis and follow-up.

Original languageEnglish
Pages (from-to)93-98
Number of pages6
JournalEuropean Journal of Pharmaceutical Sciences
Volume96
DOIs
Publication statusPublished - Jan 1 2017

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Keywords

  • Biomarkers
  • Body fluids
  • Early diagnosis
  • Exosomes
  • Extracellular vesicles
  • Follow-up
  • Prostate cancer
  • Tumor marker

ASJC Scopus subject areas

  • Pharmaceutical Science

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