TY - JOUR
T1 - Exosome levels in human body fluids
T2 - A tumor marker by themselves?
AU - Cappello, Francesco
AU - Logozzi, Mariantonia
AU - Campanella, Claudia
AU - Bavisotto, Celeste Caruso
AU - Marcilla, Antonio
AU - Properzi, Francesca
AU - Fais, Stefano
PY - 2017/1/1
Y1 - 2017/1/1
N2 - Despite considerable research efforts, the finding of reliable tumor biomarkers remains challenging and unresolved. In recent years a novel diagnostic biomedical tool with high potential has been identified in extracellular nanovesicles or exosomes. They are released by the majority of the cells and contain detailed molecular information on the cell of origin including tumor hallmarks. Exosomes can be isolated from easy accessible body fluids, and most importantly, they can provide several biomarkers, with different levels of specificity. Recent clinical evidence shows that the levels of exosomes released into body fluids may themselves represent a predictive/diagnostic of tumors, discriminating cancer patients from healthy subjects. The aim of this review is to highlight these latest challenging findings to provide novel and groundbreaking ideas for successful tumor early diagnosis and follow-up.
AB - Despite considerable research efforts, the finding of reliable tumor biomarkers remains challenging and unresolved. In recent years a novel diagnostic biomedical tool with high potential has been identified in extracellular nanovesicles or exosomes. They are released by the majority of the cells and contain detailed molecular information on the cell of origin including tumor hallmarks. Exosomes can be isolated from easy accessible body fluids, and most importantly, they can provide several biomarkers, with different levels of specificity. Recent clinical evidence shows that the levels of exosomes released into body fluids may themselves represent a predictive/diagnostic of tumors, discriminating cancer patients from healthy subjects. The aim of this review is to highlight these latest challenging findings to provide novel and groundbreaking ideas for successful tumor early diagnosis and follow-up.
KW - Biomarkers
KW - Body fluids
KW - Early diagnosis
KW - Exosomes
KW - Extracellular vesicles
KW - Follow-up
KW - Prostate cancer
KW - Tumor marker
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UR - http://www.scopus.com/inward/citedby.url?scp=84987926205&partnerID=8YFLogxK
U2 - 10.1016/j.ejps.2016.09.010
DO - 10.1016/j.ejps.2016.09.010
M3 - Article
C2 - 27640113
AN - SCOPUS:84987926205
VL - 96
SP - 93
EP - 98
JO - European Journal of Pharmaceutical Sciences
JF - European Journal of Pharmaceutical Sciences
SN - 0928-0987
ER -