TY - JOUR
T1 - Exosomes
T2 - a new horizon in lung cancer
AU - Vanni, Irene
AU - Alama, Angela
AU - Grossi, Francesco
AU - Dal Bello, Maria Giovanna
AU - Coco, Simona
PY - 2017/6/1
Y1 - 2017/6/1
N2 - Circulating exosomes are the major mediators of cell–cell communication. They have been found in various body fluids of healthy individuals and patients with malignancies as cargos of several molecules including miRNAs. Several studies have underlined the role of exosome miRNAs in different tumor types, including lung cancer, suggesting their potential use as biomarkers and therapeutic agents. An overview of the biology and function of exosomes and exosome miRNAs as indicators of diagnosis and treatment response in lung cancer is presented. In addition, preliminary data on exosomes as potential therapeutic agents are reported.
AB - Circulating exosomes are the major mediators of cell–cell communication. They have been found in various body fluids of healthy individuals and patients with malignancies as cargos of several molecules including miRNAs. Several studies have underlined the role of exosome miRNAs in different tumor types, including lung cancer, suggesting their potential use as biomarkers and therapeutic agents. An overview of the biology and function of exosomes and exosome miRNAs as indicators of diagnosis and treatment response in lung cancer is presented. In addition, preliminary data on exosomes as potential therapeutic agents are reported.
UR - http://www.scopus.com/inward/record.url?scp=85015808804&partnerID=8YFLogxK
UR - http://www.scopus.com/inward/citedby.url?scp=85015808804&partnerID=8YFLogxK
U2 - 10.1016/j.drudis.2017.03.004
DO - 10.1016/j.drudis.2017.03.004
M3 - Review article
AN - SCOPUS:85015808804
VL - 22
SP - 927
EP - 936
JO - Drug Discovery Today
JF - Drug Discovery Today
SN - 1359-6446
IS - 6
ER -