Exosomes increase the therapeutic index of doxorubicin in breast and ovarian cancer mouse models

Research output: Contribution to journalArticlepeer-review

Abstract

Aim: To demonstrate that exosomes (exo) could increase the therapeutic index of doxorubicin (DOX). Materials & methods: Exosomes were characterized by nanoparticle tracking analysis and western blot. Tissue toxicity was evaluated by histopathological analysis and drug efficacy by measuring tumor volume. DOX biodistribution was analyzed by MS. Results: Exosomal doxorubicin (exoDOX) avoids heart toxicity by partially limiting the crossing of DOX through the myocardial endothelial cells. For this reason, mice can be treated with higher concentration of exoDOX thus increasing the efficacy of DOX as demonstrated in breast and ovarian mouse tumors. Conclusion: ExoDOX is safer and more effective than free DOX. Importantly, the first spontaneous transformed syngeneic model of high-grade serous ovarian cancer was utilized for providing a new therapeutic opportunity.

Original languageEnglish
Pages (from-to)2431-2441
Number of pages11
JournalNanomedicine
Volume11
Issue number18
DOIs
Publication statusPublished - Sep 1 2016

Keywords

  • breast and ovarian cancers
  • doxorubicin
  • drug delivery
  • exosomes
  • therapeutic index

ASJC Scopus subject areas

  • Materials Science(all)
  • Bioengineering
  • Biomedical Engineering
  • Medicine (miscellaneous)
  • Development

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