Expanding lacunae causing triventricular hydrocephalus: Report of two cases

Mario Mascalchi, Fabrizio Salvi, Umberto Godano, Marco Nistri, Rosanna Taiuti, Michela Tosetti, Natale Villari, Fabio Calbucci

Research output: Contribution to journalArticlepeer-review


Two patients are reported in whom the presence of triventricular hydrocephalus and aqueductal obstruction or stenosis due to multiple expanding lacunae in the mesencephalothalamic region possibly corresponds to abnormally dilated perivascular spaces. Placement of a ventriculoperitoneal cerebrospinal fluid (CSF) shunt in one patient and the performance of a third ventricle cisternotomy in the other reversed the hydrocephalic syndrome, but did not modify the complex neuroophthalmological disturbance and rubral tremor presumably related to the compressive effects of the lacunae on adjacent parenchyma. In one patient the number and size of the lacunae were increased 4 years after CSF shunt placement. A review of the literature revealed two cases in which magnetic resonance imaging demonstrated a similar, poorly understood pathological condition.

Original languageEnglish
Pages (from-to)669-674
Number of pages6
JournalJournal of Neurosurgery
Issue number4
Publication statusPublished - Oct 1999


  • Brain lacunae
  • Hydrocephalus
  • Magnetic resonance imaging
  • Mesencephalon
  • Proton magnetic resonance spectroscopy

ASJC Scopus subject areas

  • Clinical Neurology
  • Neuroscience(all)

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