Expanding postmortem donor pool using steatotic liver grafts: A new look

Huda M. Noujaim, Jean De Ville De Goyet, Edna F S Montero, Cristiane M F Ribeiro, Vera L. Capellozzi, Fabio Crescentini, Matheo Casagrande, Regina G. Santos, Lillian Curvello, Marcelo P. De Miranda, Tercio Genzini

Research output: Contribution to journalArticlepeer-review

Abstract

BACKGROUND.: Clinical demand for liver transplant steadily grows while organs offer has reached a plateau years ago. To expand the donor liver pool, various options have been considered including acceptance of suboptimal donors and steatotic grafts, with a risk of poorer outcomes. The latter risk and its relation to the grade of liver graft steatosis have been studied in this prospective clinical study. METHODS.: One hundred eighteen consecutive liver transplantation (115 patients) performed between May 2002 and March 2008 were prospectively analyzed. According to the grade of steatosis on a 2 hr postreperfusion biopsy, four groups were considered: absence (30%) and severe steatosis (>60%) have a negative impact on outcomes. The authors conclude that using these grafts allow a significant increase in organ offer that counterbalances the negative outcome for patients who are not offered a transplant, and this supports the need for further clinical research.

Original languageEnglish
Pages (from-to)919-925
Number of pages7
JournalTransplantation
Volume87
Issue number6
DOIs
Publication statusPublished - Mar 27 2009

Keywords

  • Donor pool
  • Hepatic steatosis
  • Liver transplant
  • Marginal donors
  • Outcome

ASJC Scopus subject areas

  • Transplantation

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