Expanding postmortem donor pool using steatotic liver grafts: A new look

Huda M. Noujaim; Jean De Ville De Goyet; Edna F S Montero; Cristiane M F Ribeiro; Vera L. Capellozzi; Fabio Crescentini; Matheo Casagrande; Regina G. Santos; Lillian Curvello; Marcelo P. De Miranda; Tercio Genzini

doi:10.1097/TP.0b013e31819b3f76

Expanding postmortem donor pool using steatotic liver grafts: A new look

Huda M. Noujaim, Jean De Ville De Goyet, Edna F S Montero, Cristiane M F Ribeiro, Vera L. Capellozzi, Fabio Crescentini, Matheo Casagrande, Regina G. Santos, Lillian Curvello, Marcelo P. De Miranda, Tercio Genzini

Ospedale Pediatrico Bambino Gesu

Research output: Contribution to journal › Article › peer-review

Abstract

BACKGROUND.: Clinical demand for liver transplant steadily grows while organs offer has reached a plateau years ago. To expand the donor liver pool, various options have been considered including acceptance of suboptimal donors and steatotic grafts, with a risk of poorer outcomes. The latter risk and its relation to the grade of liver graft steatosis have been studied in this prospective clinical study. METHODS.: One hundred eighteen consecutive liver transplantation (115 patients) performed between May 2002 and March 2008 were prospectively analyzed. According to the grade of steatosis on a 2 hr postreperfusion biopsy, four groups were considered: absence (30%) and severe steatosis (>60%) have a negative impact on outcomes. The authors conclude that using these grafts allow a significant increase in organ offer that counterbalances the negative outcome for patients who are not offered a transplant, and this supports the need for further clinical research.

Original language	English
Pages (from-to)	919-925
Number of pages	7
Journal	Transplantation
Volume	87
Issue number	6
DOIs	https://doi.org/10.1097/TP.0b013e31819b3f76
Publication status	Published - Mar 27 2009

Keywords

Donor pool
Hepatic steatosis
Liver transplant
Marginal donors
Outcome

ASJC Scopus subject areas

Transplantation

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Expanding postmortem donor pool using steatotic liver grafts : A new look. / Noujaim, Huda M.; De Ville De Goyet, Jean; Montero, Edna F S; Ribeiro, Cristiane M F; Capellozzi, Vera L.; Crescentini, Fabio; Casagrande, Matheo; Santos, Regina G.; Curvello, Lillian; De Miranda, Marcelo P.; Genzini, Tercio.

In: Transplantation, Vol. 87, No. 6, 27.03.2009, p. 919-925.

Research output: Contribution to journal › Article › peer-review

Noujaim, Huda M. ; De Ville De Goyet, Jean ; Montero, Edna F S ; Ribeiro, Cristiane M F ; Capellozzi, Vera L. ; Crescentini, Fabio ; Casagrande, Matheo ; Santos, Regina G. ; Curvello, Lillian ; De Miranda, Marcelo P. ; Genzini, Tercio. / Expanding postmortem donor pool using steatotic liver grafts : A new look. In: Transplantation. 2009 ; Vol. 87, No. 6. pp. 919-925.

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abstract = "BACKGROUND.: Clinical demand for liver transplant steadily grows while organs offer has reached a plateau years ago. To expand the donor liver pool, various options have been considered including acceptance of suboptimal donors and steatotic grafts, with a risk of poorer outcomes. The latter risk and its relation to the grade of liver graft steatosis have been studied in this prospective clinical study. METHODS.: One hundred eighteen consecutive liver transplantation (115 patients) performed between May 2002 and March 2008 were prospectively analyzed. According to the grade of steatosis on a 2 hr postreperfusion biopsy, four groups were considered: absence (30%) and severe steatosis (>60%) have a negative impact on outcomes. The authors conclude that using these grafts allow a significant increase in organ offer that counterbalances the negative outcome for patients who are not offered a transplant, and this supports the need for further clinical research.",

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AU - Montero, Edna F S

AU - Ribeiro, Cristiane M F

AU - Capellozzi, Vera L.

AU - Crescentini, Fabio

AU - Casagrande, Matheo

AU - Santos, Regina G.

AU - Curvello, Lillian

AU - De Miranda, Marcelo P.

AU - Genzini, Tercio

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AB - BACKGROUND.: Clinical demand for liver transplant steadily grows while organs offer has reached a plateau years ago. To expand the donor liver pool, various options have been considered including acceptance of suboptimal donors and steatotic grafts, with a risk of poorer outcomes. The latter risk and its relation to the grade of liver graft steatosis have been studied in this prospective clinical study. METHODS.: One hundred eighteen consecutive liver transplantation (115 patients) performed between May 2002 and March 2008 were prospectively analyzed. According to the grade of steatosis on a 2 hr postreperfusion biopsy, four groups were considered: absence (30%) and severe steatosis (>60%) have a negative impact on outcomes. The authors conclude that using these grafts allow a significant increase in organ offer that counterbalances the negative outcome for patients who are not offered a transplant, and this supports the need for further clinical research.

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KW - Outcome

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Expanding postmortem donor pool using steatotic liver grafts: A new look

Abstract

Keywords

ASJC Scopus subject areas

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