Abstract
BACKGROUND.: Clinical demand for liver transplant steadily grows while organs offer has reached a plateau years ago. To expand the donor liver pool, various options have been considered including acceptance of suboptimal donors and steatotic grafts, with a risk of poorer outcomes. The latter risk and its relation to the grade of liver graft steatosis have been studied in this prospective clinical study. METHODS.: One hundred eighteen consecutive liver transplantation (115 patients) performed between May 2002 and March 2008 were prospectively analyzed. According to the grade of steatosis on a 2 hr postreperfusion biopsy, four groups were considered: absence (30%) and severe steatosis (>60%) have a negative impact on outcomes. The authors conclude that using these grafts allow a significant increase in organ offer that counterbalances the negative outcome for patients who are not offered a transplant, and this supports the need for further clinical research.
Original language | English |
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Pages (from-to) | 919-925 |
Number of pages | 7 |
Journal | Transplantation |
Volume | 87 |
Issue number | 6 |
DOIs | |
Publication status | Published - Mar 27 2009 |
Keywords
- Donor pool
- Hepatic steatosis
- Liver transplant
- Marginal donors
- Outcome
ASJC Scopus subject areas
- Transplantation