TY - JOUR
T1 - Expanding the spectrum of EWSR1-PATZ1 rearranged CNS tumors
T2 - An infantile case with leptomeningeal dissemination
AU - Rossi, Sabrina
AU - Barresi, Sabina
AU - Giovannoni, Isabella
AU - Alesi, Viola
AU - Ciolfi, Andrea
AU - Colafati, Giovanna Stefania
AU - Diomedi-Camassei, Francesca
AU - Miele, Evelina
AU - Cacchione, Antonella
AU - Quacquarini, Denise
AU - Carai, Andrea
AU - Tartaglia, Marco
AU - Giannini, Caterina
AU - Giangaspero, Felice
AU - Mastronuzzi, Angela
AU - Alaggio, Rita
N1 - © 2021 The Authors. Brain Pathology published by John Wiley & Sons Ltd on behalf of International Society of Neuropathology.
PY - 2021/5
Y1 - 2021/5
N2 - We report on a case of EWSR1-PATZ1 rearranged brain tumor occurring in a 17 month-old child, originally interpreted as an infantile glioblastoma. Our case shows important analogies with the 2 previously reported cases, including the intraventricular location, the histologic appearance (pushing borders, oligodendrocyte-like morphology, rich vascular network) and the glioneural immunophenotype, supporting the role of these features as relevant clues to the diagnosis. On the other hand, our case displays unique characteristics, i.e. the onset in an infant, the presence of a focal high-grade component and the leptomeningeal dissemination, pointing to the importance of considering this entity in the differential diagnosis of an infantile glial/glioneural tumor.
AB - We report on a case of EWSR1-PATZ1 rearranged brain tumor occurring in a 17 month-old child, originally interpreted as an infantile glioblastoma. Our case shows important analogies with the 2 previously reported cases, including the intraventricular location, the histologic appearance (pushing borders, oligodendrocyte-like morphology, rich vascular network) and the glioneural immunophenotype, supporting the role of these features as relevant clues to the diagnosis. On the other hand, our case displays unique characteristics, i.e. the onset in an infant, the presence of a focal high-grade component and the leptomeningeal dissemination, pointing to the importance of considering this entity in the differential diagnosis of an infantile glial/glioneural tumor.
U2 - 10.1111/bpa.12934
DO - 10.1111/bpa.12934
M3 - Article
C2 - 33378126
VL - 31
SP - e12934
JO - Brain Pathology
JF - Brain Pathology
SN - 1015-6305
IS - 3
ER -