Expansion of T-cell receptor ζdim effector T cells in acute coronary syndromes

Enrico Ammirati, Anna Chiara Vermi, Domenico Cianflone, Michela Banfi, Chiara Foglieni, Cosmo Godino, Flavio Airoldi, Luca A. Ferri, Claire L. Gorman, Angelo A. Manfredi, Attilio Maseri, Andrew P. Cope, Claudia Monaco

Research output: Contribution to journalArticle

Abstract

Objective - The T-cell receptor zeta (TCRζ)-chain is a master sensor and regulator of lymphocyte responses. Loss of TCRζ-chain expression has been documented during infectious and inflammatory diseases and defines a population of effector T cells (TCRζdim T cells) that migrate to inflamed tissues. We assessed the expression and functional correlates of circulating TCRζdim T cells in coronary artery disease. Methods and Results - We examined the expression of TCRζ-chain by flow cytometry in 140 subjects. Increased peripheral blood CD4+ TCRζ dim T cells were found in patients with acute coronary syndromes (ACS, n=66; median 5.3%, interquartile 2.6 to 9.1% of total CD4+ T cells; Pdim cells were also more represented within CD8+ T cell, NK, and CD4 +CD28null T cell subsets in ACS compared to CSA and controls. Finally, CD4+ and CD8+ TCRζdim T cells isolated from ACS displayed an enhanced transendothelial migratory capacity. Conclusions - TCRζdim T cells, an effector T-cell subset with transendothelial migratory ability, are increased in ACS, and may be implicated in coronary instability.

Original languageEnglish
Pages (from-to)2305-2311
Number of pages7
JournalArteriosclerosis, Thrombosis, and Vascular Biology
Volume28
Issue number12
DOIs
Publication statusPublished - Dec 2008

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Keywords

  • Acute coronary syndrome
  • Flow cytometry
  • Immune system
  • Lymphocytes
  • Receptors

ASJC Scopus subject areas

  • Cardiology and Cardiovascular Medicine

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