Expansion of Vδ1 T lymphocytes producing IL-4 in low-grade non-Hodgkin lymphomas expressing UL-16-binding proteins

Silvia Catellani, Alessandro Poggi, Andrea Bruzzone, Patrizia Dadati, Jean Louis Ravetti, Marco Gobbi, Maria Raffaella Zocchi

Research output: Contribution to journalArticle

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Abstract

Data on 23 patients with low-grade non-Hodgkin lymphomas (NHLs), 4 mantle (MT), 4 marginal zone (MZ), and 15 follicular (FL), were analyzed and compared with 10 high-risk (HR) B-cell chronic lymphocytic leukemias (B-CLLs) with lymph node involvement and 4 diffuse large-cell lymphomas (DLCLs). A significant increase in circulating Vδ1 T lymphocytes producing interleukin-4 (IL-4) was found in patients with FL, MT, and MZ NHL, at variance with DLCL and HR B-CLL. IL-4 was also detectable in the sera and lymph nodes of the same patients. In 19 of the 23 patients with NHL with increased circulating Vδ1 T lymphocytes, B cells expressing the UL-16-binding proteins (ULBPs) ULBP2 or ULBP3 or both were found in peripheral blood, bone marrow, or lymph nodes. Of note, in HR B-CLL or in DLCL, where leukemic cells were negative for ULBPs, no Vδ1 T-cell increase was found. Moreover, Vδ1 T lymphocytes from patients with FL NHL proliferate in response to ULBP2+ and ULBP3 + lymphoma cells. Finally, patients with high expression of ULBPs, increased circulating Vδ1 T lymphocytes, and high levels of serum IL-4 showed stable disease in a 1-year follow-up in contrast to patients with low circulating Vδ1 T cells and undetectable IL-4 or ULBPs.

Original languageEnglish
Pages (from-to)2078-2085
Number of pages8
JournalBlood
Volume109
Issue number5
DOIs
Publication statusPublished - Mar 1 2007

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T-cells
Interleukin-4
Non-Hodgkin's Lymphoma
Carrier Proteins
T-Lymphocytes
Lymphoma, Large B-Cell, Diffuse
B-Cell Chronic Lymphocytic Leukemia
Lymph Nodes
Cells
Mantle-Cell Lymphoma
Follicular Lymphoma
Serum
Bone
Blood
Lymphoma
B-Lymphocytes
Bone Marrow

ASJC Scopus subject areas

  • Hematology

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Expansion of Vδ1 T lymphocytes producing IL-4 in low-grade non-Hodgkin lymphomas expressing UL-16-binding proteins. / Catellani, Silvia; Poggi, Alessandro; Bruzzone, Andrea; Dadati, Patrizia; Ravetti, Jean Louis; Gobbi, Marco; Zocchi, Maria Raffaella.

In: Blood, Vol. 109, No. 5, 01.03.2007, p. 2078-2085.

Research output: Contribution to journalArticle

Catellani, Silvia ; Poggi, Alessandro ; Bruzzone, Andrea ; Dadati, Patrizia ; Ravetti, Jean Louis ; Gobbi, Marco ; Zocchi, Maria Raffaella. / Expansion of Vδ1 T lymphocytes producing IL-4 in low-grade non-Hodgkin lymphomas expressing UL-16-binding proteins. In: Blood. 2007 ; Vol. 109, No. 5. pp. 2078-2085.
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